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    mapk12.S mitogen-activated protein kinase 12 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398592, updated on 4-Nov-2024

    Summary

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    Official Symbol
    mapk12.S
    Official Full Name
    mitogen-activated protein kinase 12 S homeolog
    Primary source
    Xenbase:XB-GENE-485786
    Locus tag
    XELAEV_18021031mg
    See related
    EnsemblRapid:ENSXLAG00005007265 AllianceGenome:Xenbase:XB-GENE-485786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    sapk3; mapk12; Xp38gamma
    Summary
    Predicted to enable ATP binding activity and MAP kinase activity. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mapk12.S in Genome Data Viewer
    Location:
    chromosome: 3S
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (77161823..77204396, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (75730209..75772855, complement)

    Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene TraB domain containing S homeolog Neighboring gene sizzled S homeolog Neighboring gene mitogen-activated protein kinase 11 S homeolog Neighboring gene uncharacterized LOC121402186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C. Perdiguero E, et al. EMBO J, 2003 Nov 3. PMID 14592973, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 12 S homeolog
    Names
    SAPK3 protein kinase
    Xp38gamma/SAPK3 protein kinase
    NP_001082596.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089127.1 → NP_001082596.1  mitogen-activated protein kinase 12 S homeolog

      See identical proteins and their annotated locations for NP_001082596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068708
      UniProtKB/TrEMBL
      A0A974HRJ0, Q7ZZX6
      Related
      ENSXLAP00005020860.1, ENSXLAT00005021452.1
      Conserved Domains (2) summary
      cd07880
      Location:11 → 353
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)
      smart00220
      Location:33 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      77161823..77204396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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