narfl nuclear prelamin A recognition factor-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: narflprovided by ZNC
Official Full Name: nuclear prelamin A recognition factor-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070209-119
See related: Ensembl:ENSDARG00000062216 AllianceGenome:ZFIN:ZDB-GENE-070209-119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7151348; zgc:158422
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Involved in regulation of angiogenesis. Acts upstream of or within sprouting angiogenesis. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (18756231..18769951)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (18606491..18620211)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish.
Title: Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytosolic Fe-S cluster assembly factor narfl

Names: nuclear prelamin A recognition factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080991.2 → NP_001074460.2 cytosolic Fe-S cluster assembly factor narfl

Status: VALIDATED

Source sequence(s)

AL772362, BC131874, EE309978

UniProtKB/Swiss-Prot

A2RRV9

UniProtKB/TrEMBL

G1K2S6

Related

ENSDARP00000084112.5, ENSDART00000089679.7

Conserved Domains (3) summary

smart00902
Location:419 → 467

Fe_hyd_SSU; Iron hydrogenase small subunit

COG4624
Location:61 → 463

Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]

pfam02906
Location:118 → 405

Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain