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    Kmt2d lysine methyltransferase 2D [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100765465, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Kmt2d
    Gene description
    lysine methyltransferase 2D
    Locus tag
    I79_019112
    See related
    Ensembl:ENSCGRG00015006042
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt2d in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614949.1 (126462..164801)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (395304818..395343250, complement)

    NW_003614949.1Genomic Context describing neighboring genes Neighboring gene desert hedgehog signaling molecule Neighboring gene RHEB like 1 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene dendrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase 2D
    Names
    Histone-lysine N-methyltransferase MLL2
    lysine (K)-specific methyltransferase 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003614949.1 Reference CriGri_1.0 Primary Assembly

      Range
      126462..164801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_035461368.1 → XP_035317259.1  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D isoform X1

      UniProtKB/TrEMBL
      A0A8C2LIQ8
      Conserved Domains (15) summary
      TIGR01645
      Location:4230 → 4423
      half-pint; poly-U binding splicing factor, half-pint family
      smart00398
      Location:2014 → 2065
      HMG; high mobility group
      smart00542
      Location:5195 → 5282
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2100 → 2669
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:268 → 282
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1423 → 1469
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1372 → 1422
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1500 → 1550
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4987 → 5093
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3946 → 4299
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19209
      Location:5337 → 5491
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      pfam05964
      Location:5136 → 5187
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:276 → 320
      PHD_SF; PHD finger superfamily

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048595.1 Alternate CriGri-PICRH-1.0

      Range
      395304818..395343250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027396486.2 → XP_027252287.1  histone-lysine N-methyltransferase 2D isoform X6

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7JC23

    2. XM_027396487.2 → XP_027252288.1  histone-lysine N-methyltransferase 2D isoform X7

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7F783
      Related
      ENSCGRP00015008209.2, ENSCGRT00015010129.2

    3. XM_027396485.2 → XP_027252286.1  histone-lysine N-methyltransferase 2D isoform X5

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7JC31

    4. XM_027396489.2 → XP_027252290.1  histone-lysine N-methyltransferase 2D isoform X9

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7F6G5

    5. XM_027396484.2 → XP_027252285.1  histone-lysine N-methyltransferase 2D isoform X4

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7J6W4

    6. XM_035440859.1 → XP_035296750.1  histone-lysine N-methyltransferase 2D isoform X12

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7GS57
      Conserved Domains (14) summary
      smart00398
      Location:2020 → 2071
      HMG; high mobility group
      smart00542
      Location:5193 → 5280
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2109 → 2675
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:268 → 282
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1424 → 1470
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1373 → 1423
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1501 → 1551
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4985 → 5091
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3977 → 4366
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19209
      Location:5351 → 5505
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      pfam05964
      Location:5134 → 5185
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:276 → 320
      PHD_SF; PHD finger superfamily

    7. XM_027396482.2 → XP_027252283.1  histone-lysine N-methyltransferase 2D isoform X2

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7JA16

    8. XM_027396488.2 → XP_027252289.1  histone-lysine N-methyltransferase 2D isoform X8

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7FAZ4

    9. XM_027396483.2 → XP_027252284.1  histone-lysine N-methyltransferase 2D isoform X3

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7F9G9

    10. XM_027396490.2 → XP_027252291.1  histone-lysine N-methyltransferase 2D isoform X10

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7FBF0
      Related
      ENSCGRP00015008030.2, ENSCGRT00015009906.2

    11. XM_027396493.2 → XP_027252294.1  histone-lysine N-methyltransferase 2D isoform X1

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7FAP3

    12. XM_027396492.1 → XP_027252293.1  histone-lysine N-methyltransferase 2D isoform X11

      UniProtKB/TrEMBL
      A0A8C2LIQ8, A0A9J7JDJ6
    Nucleotide Protein Strain
    Heading Accession and Version

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