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    Catsper3 cation channel, sperm associated 3 [ Mus musculus (house mouse) ]

    Gene ID: 76856, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Catsper3provided by MGI
    Official Full Name
    cation channel, sperm associated 3provided by MGI
    Primary source
    MGI:MGI:1924106
    See related
    Ensembl:ENSMUSG00000021499 AllianceGenome:MGI:1924106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CACRC; 4921522D01Rik
    Summary
    Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and endoplasmic reticulum. Part of CatSper complex. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human CATSPER3 (cation channel sperm associated 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis adult (RPKM 22.1) See more
    Orthologs
    human all
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    Genomic context

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    See Catsper3 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55932313..55971861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55784500..55824048)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 15 Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 Neighboring gene RIKEN cDNA 4930451E10 gene Neighboring gene STARR-seq mESC enhancer starr_34625 Neighboring gene STARR-seq mESC enhancer starr_34626 Neighboring gene paired-like homeodomain transcription factor 1 Neighboring gene predicted gene, 31542

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. H2O2-induced up-regulation of CatSper3 in mouse brain. Kim CW, et al. Mol Reprod Dev, 2010 Aug. PMID 20586097
    2. Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Jin J, et al. Biol Reprod, 2007 Jul. PMID 17344468
    3. Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers. Bystroff C. Reprod Biol, 2018 Mar. PMID 29371110, Free PMC Article
    4. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. Lobley A, et al. Reprod Biol Endocrinol, 2003 Aug 1. PMID 12932298, Free PMC Article
    5. Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Jin JL, et al. Biol Reprod, 2005 Dec. PMID 16107607

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.
      Title: Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.
    2. Hydrogen peroxide induced upregulation of catsper3 in brain.
      Title: H2O2-induced up-regulation of CatSper3 in mouse brain.
    3. Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3.
      Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
    4. Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
      Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
    5. Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
      Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
    6. CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility
      Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC107210

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252487.1 → NP_001239416.1  cation channel sperm-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001239416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC129780
      Consensus CDS
      CCDS56885.1
      UniProtKB/Swiss-Prot
      Q5FWA9, Q80W99, Q9D5T9
      UniProtKB/TrEMBL
      E0Z0E0
      Related
      ENSMUSP00000021961.6, ENSMUST00000021961.12
      Conserved Domains (1) summary
      pfam00520
      Location:49 → 269
      Ion_trans; Ion transport protein

    2. NM_001252488.1 → NP_001239417.1  cation channel sperm-associated protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001239417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC129780
      UniProtKB/TrEMBL
      E0Z0E1
      Conserved Domains (1) summary
      pfam00520
      Location:100 → 218
      Ion_trans; Ion transport protein

    3. NM_029772.4 → NP_084048.1  cation channel sperm-associated protein 3 isoform 2

      See identical proteins and their annotated locations for NP_084048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC129780, AK014942
      Consensus CDS
      CCDS26555.1
      UniProtKB/Swiss-Prot
      Q80W99
      Related
      ENSMUSP00000105524.3, ENSMUST00000109898.3
      Conserved Domains (1) summary
      pfam00520
      Location:138 → 256
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55932313..55971861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517455.3 → XP_006517518.1  cation channel sperm-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006517518.1

      UniProtKB/Swiss-Prot
      Q5FWA9, Q80W99, Q9D5T9
      UniProtKB/TrEMBL
      E0Z0E0
      Conserved Domains (1) summary
      pfam00520
      Location:49 → 269
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W99.2 GenPept UniProtKB/Swiss-Prot:Q80W99

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