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    BARF1 protein BARF1 [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

    Gene ID: 3783772, updated on 20-Nov-2023

    Summary

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    Gene symbol
    BARF1
    Gene description
    protein BARF1
    Locus tag
    HHV4_BARF1.2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
    Lineage
    Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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    Genomic context

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    Sequence:
    NC_007605.1 (165008..165712)

    NC_007605.1Genomic Context describing neighboring genes Neighboring gene DNA packaging terminase subunit 2 Neighboring gene single-stranded DNA-binding protein Neighboring gene apoptosis regulator BALF1 Neighboring gene membrane protein LMP-2A Neighboring gene protein BNLF2b Neighboring gene protein BNLF2a Neighboring gene latent membrane protein LMP-1 Neighboring gene membrane protein LMP-2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007605.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells. Mohidin TB, et al. J Biosci, 2015 Mar. PMID 25740140
    2. Cellular localization of BARF1 oncoprotein and its cell stimulating activity in human epithelial cell. Sakka E, et al. Virus Res, 2013 Jun. PMID 23458996
    3. Role of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesis. Takada K. Semin Cancer Biol, 2012 Apr. PMID 22210180
    4. Post-translational modifications of Epstein Barr virus BARF1 oncogene-encoded polypeptide. de Turenne-Tessier M, et al. J Gen Virol, 2007 Oct. PMID 17872516
    5. Differential expression of EBV proteins LMP1 and BHFR1 in EBV‑associated gastric and nasopharyngeal cancer tissues. Wang A, et al. Mol Med Rep, 2016 May. PMID 27052804, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epstein Barr virus-encoded BARF1 promotes cell proliferation in stomach cancer by upregulating NFkappaB and miR-146a and downregulating SMAD4, thereby contributing to EBV-induced stomach cancer progression.
      Title: Epstein-Barr virus BARF1-induced NFκB/miR-146a/SMAD4 alterations in stomach cancer cells.
    2. EBV infection exhibits a role in gastric cancer and NPC development; however, expression of EBVassociated proteins LMP1 and BARF1 have differential functions during tumorigenesis of these two types of cancer.
      Title: Differential expression of EBV proteins LMP1 and BHFR1 in EBV‑associated gastric and nasopharyngeal cancer tissues.
    3. siRNA-mediated BARF1 down-regulation induces caspase-dependent apoptosis via the mitochondrial pathway through modulation of Bcl-2/BAX ratio in AG876 and Hone-Akata cells.
      Title: BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells.
    4. In BARF1-transfected cells, cell growth was activated and its protein was found both in culture medium and cellular compartment (membrane, cytoplasm and nuclei).
      Title: Cellular localization of BARF1 oncoprotein and its cell stimulating activity in human epithelial cell.
    5. These results indicate that BARF1 blockade of CSF-1 signaling is an important immune evasion strategy for efficient acute EBV infection and a significant determinant for virus setpoint during persistent EBV infection.
      Title: An Epstein-Barr virus encoded inhibitor of Colony Stimulating Factor-1 signaling is an important determinant for acute and persistent EBV infection.
    6. M-CSF was shown to interact with Epstein-Barr virus-encoded BARF1 via the protruding N-terminal loops involving Val38 and Ala84.
      Title: Epstein-Barr virus-encoded BARF1 protein is a decoy receptor for macrophage colony stimulating factor and interferes with macrophage differentiation and activation.
    7. expression of the BARF1 protein during lytic replication is regulated by direct binding of BRLF1 to multiple R-responsive elements in the gene control region and is independent of the promoter methylation status
      Title: Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation.
    8. Studies indicate that BARF1 is expressed as a latent gene in nasopharyngeal carcinoma (NPC), and that BARF1 contributes to the tumorigenicity of NPC cells.
      Title: Role of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesis.
    9. The N- and O-glycans were partially characterized and it was demonstrated that both modifications are required for active secretion of the BARF1 protein via the classical pathway.
      Title: Post-translational modifications of Epstein Barr virus BARF1 oncogene-encoded polypeptide.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: 165008-165013 regulatory_class = TATA_box
    • Loc: 165707-165712 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    protein BARF1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007605.1 Reference assembly

      Range
      165008..165712
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_401719.1 protein BARF1 [Human gammaherpesvirus 4]

      See identical proteins and their annotated locations for YP_401719.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03228, P0C6N0, P0CW72, Q777A5
      UniProtKB/TrEMBL
      A0A0B6VMU8, A0A0C7T6E2, A0A0C7TC16, A0A2S1MQI6, A0A385J8V6, A0A3R5X7G0, G3CUP1, G3E2T9, G3E2V0, G3E2Y9, G3E2Z3, G3E306
      Conserved Domains (1) summary
      PHA03376
      Location:1 → 221
      PHA03376; BARF1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW72.1

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