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    Mtg2 mitochondrial ribosome associated GTPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 52856, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mtg2provided by MGI
    Official Full Name
    mitochondrial ribosome associated GTPase 2provided by MGI
    Primary source
    MGI:MGI:106565
    See related
    Ensembl:ENSMUSG00000039069 AllianceGenome:MGI:106565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtpbp5; D2Bwg0647e; 1810011P19Rik; 2900056P18Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrion. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtg2 in Genome Data Viewer
    Location:
    2 H4; 2 102.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179712366..179727695)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180070573..180085902)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 7 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene histamine receptor H3 Neighboring gene predicted gene, 46782

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of respiratory system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosome-associated GTPase 2
    Names
    GTP binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083328.1 → NP_001076797.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_001076797.1

      Status: VALIDATED

      Source sequence(s)
      BC028465, BF012021, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    2. NM_001083329.1 → NP_001076798.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_001076798.1

      Status: VALIDATED

      Source sequence(s)
      AW647214, BC028465, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Related
      ENSMUSP00000104529.2, ENSMUST00000108901.8
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    3. NM_028422.1 → NP_082698.1  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_082698.1

      Status: VALIDATED

      Source sequence(s)
      BC028465, BY726952, CX210755, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    4. NM_181424.3 → NP_852089.2  mitochondrial ribosome-associated GTPase 2

      See identical proteins and their annotated locations for NP_852089.2

      Status: VALIDATED

      Source sequence(s)
      BC028465, BY726952, DT929445
      Consensus CDS
      CCDS38374.1
      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179712366..179727695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162385.1 → XP_036018278.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 271
      Obg_CgtA; Obg family GTPase CgtA

    2. XM_036162375.1 → XP_036018268.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142 → 417
      Obg_CgtA; Obg family GTPase CgtA

    3. XM_036162378.1 → XP_036018271.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    4. XM_030251869.2 → XP_030107729.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    5. XM_036162380.1 → XP_036018273.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    6. XM_036162389.1 → XP_036018282.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117 → 229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. XM_006500675.2 → XP_006500738.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_006500738.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    8. XM_030251872.2 → XP_030107732.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 271
      Obg_CgtA; Obg family GTPase CgtA

    9. XM_030251865.2 → XP_030107725.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142 → 417
      Obg_CgtA; Obg family GTPase CgtA

    10. XM_017319125.2 → XP_017174614.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    11. XM_030251871.2 → XP_030107731.1  mitochondrial ribosome-associated GTPase 2 isoform X7

      Conserved Domains (1) summary
      TIGR02729
      Location:52 → 327
      Obg_CgtA; Obg family GTPase CgtA

    12. XM_011239951.2 → XP_011238253.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_011238253.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    13. XM_030251873.2 → XP_030107733.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 271
      Obg_CgtA; Obg family GTPase CgtA

    14. XM_006500676.2 → XP_006500739.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      See identical proteins and their annotated locations for XP_006500739.1

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    15. XM_030251875.2 → XP_030107735.1  mitochondrial ribosome-associated GTPase 2 isoform X10

      UniProtKB/TrEMBL
      I6L986
      Conserved Domains (1) summary
      pfam01018
      Location:107 → 222
      GTP1_OBG; GTP1/OBG

    16. XM_036162377.1 → XP_036018270.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    17. XM_036162376.1 → XP_036018269.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Conserved Domains (1) summary
      TIGR02729
      Location:142 → 417
      Obg_CgtA; Obg family GTPase CgtA

    18. XM_036162383.1 → XP_036018276.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 271
      Obg_CgtA; Obg family GTPase CgtA

    19. XM_036162387.1 → XP_036018280.1  mitochondrial ribosome-associated GTPase 2 isoform X10

      UniProtKB/TrEMBL
      I6L986
      Related
      ENSMUSP00000139273.2, ENSMUST00000184862.8
      Conserved Domains (1) summary
      pfam01018
      Location:107 → 222
      GTP1_OBG; GTP1/OBG

    20. XM_036162388.1 → XP_036018281.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117 → 229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    21. XM_006500672.2 → XP_006500735.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      See identical proteins and their annotated locations for XP_006500735.1

      Conserved Domains (1) summary
      TIGR02729
      Location:142 → 417
      Obg_CgtA; Obg family GTPase CgtA

    22. XM_036162384.1 → XP_036018277.1  mitochondrial ribosome-associated GTPase 2 isoform X8

      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 271
      Obg_CgtA; Obg family GTPase CgtA

    23. XM_036162382.1 → XP_036018275.1  mitochondrial ribosome-associated GTPase 2 isoform X7

      Conserved Domains (1) summary
      TIGR02729
      Location:52 → 327
      Obg_CgtA; Obg family GTPase CgtA

    24. XM_036162379.1 → XP_036018272.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    25. XM_036162390.1 → XP_036018283.1  mitochondrial ribosome-associated GTPase 2 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:117 → 229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    26. XM_030251868.2 → XP_030107728.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      A2AFK4
      Conserved Domains (1) summary
      TIGR02729
      Location:112 → 387
      Obg_CgtA; Obg family GTPase CgtA

    27. XM_017319124.1 → XP_017174613.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      Conserved Domains (1) summary
      TIGR02729
      Location:222 → 497
      Obg_CgtA; Obg family GTPase CgtA

    28. XM_006500674.2 → XP_006500737.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      Conserved Domains (1) summary
      TIGR02729
      Location:222 → 381
      Obg_CgtA; Obg family GTPase CgtA

    29. XM_006500677.3 → XP_006500740.1  mitochondrial ribosome-associated GTPase 2 isoform X5

      Conserved Domains (1) summary
      pfam01018
      Location:217 → 332
      GTP1_OBG; GTP1/OBG

    30. XM_036162386.1 → XP_036018279.1  mitochondrial ribosome-associated GTPase 2 isoform X9

      Conserved Domains (1) summary
      pfam01018
      Location:217 → 264
      GTP1_OBG; GTP1/OBG

    31. XM_036162381.1 → XP_036018274.1  mitochondrial ribosome-associated GTPase 2 isoform X6

      Conserved Domains (1) summary
      cl38936
      Location:227 → 339
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_003953669.1 RNA Sequence

    2. XR_004940655.1 RNA Sequence

    3. XR_001783146.2 RNA Sequence

    4. XR_003953667.2 RNA Sequence

    5. XR_003953670.2 RNA Sequence

    6. XR_003953668.2 RNA Sequence

    7. XR_004940653.1 RNA Sequence

    8. XR_004940654.1 RNA Sequence

    9. XR_375400.3 RNA Sequence

    10. XR_003953666.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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