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    PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Gopherus evgoodei (Goodes thornscrub tortoise) ]

    Gene ID: 115653528, updated on 17-Mar-2024

    Summary

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    Gene symbol
    PIK3R1
    Gene description
    phosphoinositide-3-kinase regulatory subunit 1
    See related
    Ensembl:ENSGEVG00005019621
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gopherus evgoodei
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Testudinoidea; Testudinidae; Gopherus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    100 current rGopEvg1_v1.p (GCF_007399415.2) 6 NC_044327.1 (92949896..93020787, complement)

    Chromosome 6 - NC_044327.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 5 Neighboring gene zinc finger BED domain-containing protein 5-like Neighboring gene uncharacterized LOC115654013 Neighboring gene src substrate protein p85 pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_044327.1 Chromosome 6 Reference rGopEvg1_v1.p Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gopherus evgoodei Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference rGopEvg1_v1.p Primary Assembly

    Genomic

    1. NC_044327.1 Reference rGopEvg1_v1.p Primary Assembly

      Range
      92949896..93020787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030566902.1 → XP_030422762.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C4YM01, A0A8C4YP23
      Related
      ENSGEVP00005027814.1, ENSGEVT00005029248.1
      Conserved Domains (5) summary
      cd09930
      Location:617 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:325 → 435
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:440 → 600
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:114 → 302
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    2. XM_030566903.1 → XP_030422763.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C4YM01
      Conserved Domains (4) summary
      cd09930
      Location:554 → 657
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:262 → 372
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:377 → 537
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:51 → 239
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    3. XM_030566904.1 → XP_030422764.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

      Conserved Domains (3) summary
      cd09930
      Location:347 → 450
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:55 → 165
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:170 → 330
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    Nucleotide Protein
    Heading Accession and Version

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