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    CFLAR CASP8 and FADD like apoptosis regulator [ Rhinopithecus roxellana (golden snub-nosed monkey) ]

    Gene ID: 104671861, updated on 12-Mar-2024

    Summary

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    Gene symbol
    CFLAR
    Gene description
    CASP8 and FADD like apoptosis regulator
    See related
    Ensembl:ENSRROG00000044721
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rhinopithecus roxellana
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus
    Orthologs
    human mouse all
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    Genomic context

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    See CFLAR in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    101 current ASM756505v1 (GCF_007565055.1) 14 NC_044562.1 (88142159..88189463)
    100 previous assembly Rrox_v1 (GCF_000769185.1) Unplaced Scaffold NW_010817962.1 (171410..218258)

    Chromosome 14 - NC_044562.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115893199 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene inosine-5'-monophosphate dehydrogenase 1 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene caspase 10 Neighboring gene protein shisa-5 pseudogene Neighboring gene caspase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CASP8 and FADD-like apoptosis regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rhinopithecus roxellana Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM756505v1 Primary Assembly

    Genomic

    1. NC_044562.1 Reference ASM756505v1 Primary Assembly

      Range
      88142159..88189463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010375493.2 → XP_010373795.2  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A2K6RQN3
      Conserved Domains (3) summary
      smart00115
      Location:272 → 507
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:29 → 108
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:119 → 199
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    2. XM_010375497.2 → XP_010373799.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      A0A2K6RQL8
      Related
      ENSRROP00000043342.1
      Conserved Domains (2) summary
      cd08337
      Location:29 → 108
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:119 → 199
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    3. XM_010375495.2 → XP_010373797.2  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A2K6RQN3
      Conserved Domains (3) summary
      smart00115
      Location:272 → 507
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:29 → 108
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:119 → 199
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    4. XM_010375494.2 → XP_010373796.2  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A2K6RQN3
      Conserved Domains (3) summary
      smart00115
      Location:272 → 507
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:29 → 108
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:119 → 199
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    5. XM_030916356.1 → XP_030772216.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      A0A2K6RQL8
      Conserved Domains (2) summary
      cd08337
      Location:29 → 108
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:119 → 199
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    Nucleotide Protein
    Heading Accession and Version

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