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    stat6 signal transducer and activator of transcription 6 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100485184, updated on 4-Nov-2024

    Summary

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    Official Symbol
    stat6provided by Xenbase
    Official Full Name
    signal transducer and activator of transcription 6provided by Xenbase
    Primary source
    Xenbase:XB-GENE-484108
    See related
    Ensembl:ENSXETG00000004431 AllianceGenome:Xenbase:XB-GENE-484108
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stat6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (139259087..139332239, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (136003166..136071655, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene nuclear envelope integral membrane protein 1 Neighboring gene NGFI-A binding protein 2 (EGR1 binding protein 2) Neighboring gene LDL receptor related protein 1 Neighboring gene neurexophilin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 6
    Names
    signal transducer and activator of transcription 6, interleukin-4 induced

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      139259087..139332239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002939709.4 → XP_002939755.1  signal transducer and activator of transcription 6

      UniProtKB/TrEMBL
      A0A6I8R6D4, A0A6I8S5X0
      Related
      ENSXETP00000081214.1, ENSXETT00000089847.2
      Conserved Domains (4) summary
      cd10377
      Location:510 → 638
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      cd16856
      Location:107 → 271
      STAT6_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 6 (STAT6)
      cd16850
      Location:268 → 427
      STAT6_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 6 (STAT6)
      pfam02865
      Location:5 → 111
      STAT_int; STAT protein, protein interaction domain
    Nucleotide Protein Strain
    Heading Accession and Version

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