BRCA1 BRCA1 DNA repair associated [Papio anubis (olive baboon)] - Gene

Summary

Gene symbol: BRCA1
Gene description: BRCA1 DNA repair associated
See related: Ensembl:ENSPANG00000021372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Papio anubis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Papio
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
104	current	Panubis1.0 (GCF_008728515.1)	17	NC_044992.1 (50245753..50328270, complement)
103	previous assembly	Panu_3.0 (GCF_000264685.3)	16	NC_018167.2 (49951350..50048361, complement)

Chromosome 17 - NC_044992.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:454458 (e-PCR)
- UniSTS:157440

RH79896 (e-PCR)
- UniSTS:90392

PMC13918P1 (e-PCR)
- UniSTS:270877

G60034 (e-PCR)
- UniSTS:137300

BRCA1 (e-PCR)
- UniSTS:262743

PMC310899P11 (e-PCR)
- UniSTS:272801

PMC310899P2 (e-PCR)
- UniSTS:272804

PMC310899P3 (e-PCR)
- UniSTS:272805

BRCA1 (e-PCR)
- UniSTS:480215

GDB:454278 (e-PCR)
- UniSTS:157425

GDB:454349 (e-PCR)
- UniSTS:157426

GDB:454372 (e-PCR)
- UniSTS:157428

GDB:454417 (e-PCR)
- UniSTS:157430

GDB:454425 (e-PCR)
- UniSTS:157432

GDB:454429 (e-PCR)
- UniSTS:157433

GDB:454433 (e-PCR)
- UniSTS:157434

GDB:454437 (e-PCR)
- UniSTS:157435

GDB:454446 (e-PCR)
- UniSTS:157437

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dosage compensation by inactivation of X chromosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of BRCA1-BARD1 complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: breast cancer type 1 susceptibility protein

Names: breast cancer type 1 susceptibility protein homolog

NP_001289032.1

EC 2.3.2.27

XP_031512807.1

EC 2.3.2.27

XP_031512808.1

EC 2.3.2.27

XP_031512809.1

EC 2.3.2.27

XP_031512810.1

EC 2.3.2.27

XP_031512811.1

EC 2.3.2.27

XP_031512812.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302103.1 → NP_001289032.1 breast cancer type 1 susceptibility protein

See identical proteins and their annotated locations for NP_001289032.1

Status: PROVISIONAL

Source sequence(s)

KM017629

UniProtKB/TrEMBL

A0A075VSV6, A0A096P5X3

Related

ENSPANP00000020748.3, ENSPANT00000012331.3

Conserved Domains (4) summary

smart00292
Location:1758 → 1842

BRCT; breast cancer carboxy-terminal domain

cd00027
Location:1650 → 1724

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cd00162
Location:23 → 68

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam12820
Location:344 → 507

BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Papio anubis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Panubis1.0 Primary Assembly

Genomic

NC_044992.1 Reference Panubis1.0 Primary Assembly

Range

50245753..50328270 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031656948.1 → XP_031512808.1 breast cancer type 1 susceptibility protein isoform X2

UniProtKB/TrEMBL

A0A096P5X3

Conserved Domains (4) summary

cd16498
Location:4 → 51

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1743 → 1840

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1635 → 1731

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:330 → 492

BRCT_assoc; Serine-rich domain associated with BRCT
XM_031656949.1 → XP_031512809.1 breast cancer type 1 susceptibility protein isoform X3

UniProtKB/TrEMBL

A0A096P5X3

Conserved Domains (4) summary

cd16498
Location:4 → 51

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1638 → 1735

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1530 → 1626

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:331 → 493

BRCT_assoc; Serine-rich domain associated with BRCT
XM_031656947.1 → XP_031512807.1 breast cancer type 1 susceptibility protein isoform X1

UniProtKB/TrEMBL

A0A096P5X3

Conserved Domains (4) summary

cd16498
Location:4 → 51

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1743 → 1840

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1635 → 1731

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:331 → 493

BRCT_assoc; Serine-rich domain associated with BRCT
XM_031656951.1 → XP_031512811.1 breast cancer type 1 susceptibility protein isoform X5

Conserved Domains (3) summary

cd16498
Location:4 → 51

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:837 → 934

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:729 → 825

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
XM_031656952.1 → XP_031512812.1 breast cancer type 1 susceptibility protein isoform X6

UniProtKB/TrEMBL

A0A2I3N277

Related

ENSPANP00000042124.2, ENSPANT00000059342.2

Conserved Domains (4) summary

TIGR00599
Location:2 → 123

rad18; DNA repair protein rad18

cd16498
Location:4 → 51

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:602 → 699

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:494 → 590

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
XM_031656950.1 → XP_031512810.1 breast cancer type 1 susceptibility protein isoform X4

UniProtKB/TrEMBL

A0A2I3N412

Conserved Domains (3) summary

cd17721
Location:1631 → 1728

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1523 → 1619

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:218 → 380

BRCT_assoc; Serine-rich domain associated with BRCT