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    LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

    Gene ID: 10161, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LPAR6provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:15520
    See related
    Ensembl:ENSG00000139679 MIM:609239; AllianceGenome:HGNC:15520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5
    Summary
    The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LPAR6 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48389571..48444669, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47609888..47664937, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985274..49018805, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC112268118 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:48985733-48986234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5334 Neighboring gene uncharacterized LOC124903173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7731 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene uncharacterized LOC124903174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7733 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5336

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Shimomura Y, et al. Nat Genet, 2008 Mar. PMID 18297072
    2. Novel mutations in the P2RY5 gene in one Turkish and two Indian patients presenting with hypotrichosis and woolly hair. Pasternack SM, et al. Arch Dermatol Res, 2009 Sep. PMID 19529952
    3. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. Yanagida K, et al. J Biol Chem, 2009 Jun 26. PMID 19386608, Free PMC Article
    4. A novel mutation in lysophosphatidic acid receptor 6 gene in autosomal recessive hypotrichosis and evidence for a founder effect. Azhar A, et al. Eur J Dermatol, 2012 Jul-Aug. PMID 22531990
    5. Identification of an Alu-mediated 12.2-kb deletion of the complete LPAR6 (P2RY5) gene in a Turkish family with hypotrichosis and woolly hair. Mahmoudi H, et al. Exp Dermatol, 2012 Jun. PMID 22621192

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis.
      Title: Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis.
    2. Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
      Title: Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
    3. Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
      Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
    4. Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
      Title: Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
    5. A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
      Title: A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
    6. A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
      Title: A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
    7. Study revealed a novel homozygous missense mutation c.47A>T (p.Lys16Met) in the LPAR6 gene in Pakistani family with autosomal recessive wooly hair/hypotrichosis.
      Title: Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families.
    8. LPAR6 was downregulated in breast cancer(BC), and low LPAR6 expression was related to poor prognosis. The anti-tumor drug 5-Aza significantly upregulated LPAR6 expression in vitro, and LPAR6 might act as a tumor suppressor in BC.
      Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Expression and Prospective Signaling Pathway Analysis in Breast Cancer.
    9. mRNA expression analyses revealed that ADSCs and MES largely expressed LPA receptor 1 (LPAR1) while epithelial cells mainly expressed LPAR6. LPA 18:1 activated all the cell populations and cell lines by rise in cytosolic free calcium concentrations. MES and ADSCs expressed ATX whereas epithelial cells did not.
      Title: ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
    10. Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in three consanguineous Pakistani families.
      Title: Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hypotrichosis 8
    MedGen: C3279470 OMIM: 278150 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC120358

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysophosphatidic acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blastocyst hatching IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 6
    Names
    G-protein coupled purinergic receptor P2Y5
    LPA receptor 6
    P2Y purinoceptor 5
    RB intron encoded G-protein coupled receptor
    oleoyl-L-alpha-lysophosphatidic acid receptor
    purinergic receptor 5
    purinergic receptor P2Y G protein-coupled protein 5
    purinergic receptor P2Y, G-protein coupled, 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012874.2 RefSeqGene

      Range
      36556..38531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001162497.3 → NP_001155969.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
      UniProtKB/TrEMBL
      B3KVQ5
      Related
      ENSP00000344353.2, ENST00000345941.2
      Conserved Domains (1) summary
      cd15156
      Location:18 → 302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001162498.3 → NP_001155970.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
      UniProtKB/TrEMBL
      B3KVQ5
      Related
      ENSP00000482660.1, ENST00000620633.5
      Conserved Domains (1) summary
      cd15156
      Location:18 → 302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001377316.2 → NP_001364245.1  lysophosphatidic acid receptor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
      UniProtKB/TrEMBL
      B3KVQ5
      Conserved Domains (1) summary
      cd15156
      Location:18 → 302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001377317.2 → NP_001364246.1  lysophosphatidic acid receptor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
      UniProtKB/TrEMBL
      B3KVQ5
      Conserved Domains (1) summary
      cd15156
      Location:18 → 302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_005767.7 → NP_005758.2  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_005758.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
      UniProtKB/TrEMBL
      B3KVQ5
      Related
      ENSP00000367691.3, ENST00000378434.8
      Conserved Domains (1) summary
      cd15156
      Location:18 → 302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      48389571..48444669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430024.1 → XP_047285980.1  lysophosphatidic acid receptor 6 isoform X3

    2. XM_047430023.1 → XP_047285979.1  lysophosphatidic acid receptor 6 isoform X2

    3. XM_047430021.1 → XP_047285977.1  lysophosphatidic acid receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

    4. XM_047430019.1 → XP_047285975.1  lysophosphatidic acid receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

    5. XM_047430022.1 → XP_047285978.1  lysophosphatidic acid receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

    6. XM_047430020.1 → XP_047285976.1  lysophosphatidic acid receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      47609888..47664937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373988.1 → XP_054229963.1  lysophosphatidic acid receptor 6 isoform X3

    2. XM_054373987.1 → XP_054229962.1  lysophosphatidic acid receptor 6 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43657.3 GenPept UniProtKB/Swiss-Prot:P43657

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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