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    sars9b ORF9b protein [ SARS coronavirus Tor2 ]

    Gene ID: 1489679, updated on 7-Jul-2024

    Summary

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    Gene symbol
    sars9b
    Gene description
    ORF9b protein
    Locus tag
    sars9b
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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    Genomic context

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    Sequence:
    NC_004718.3 (28130..28426)

    NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein Neighboring gene ORF9a protein;nucleocapsid protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004718.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [The cloning, expression and structural analysis of putative unknown protein Orf 9b in SARS-CoV]. Li W, et al. Bing Du Xue Bao, 2009 Jul. PMID 19769160
    2. The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus. Meier C, et al. Structure, 2006 Jul. PMID 16843897, Free PMC Article
    3. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. Brandherm L, et al. Int J Mol Sci, 2021 Aug 26. PMID 34502139, Free PMC Article
    4. Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo. Calvo E, et al. Virus Res, 2012 Oct. PMID 22820404, Free PMC Article
    5. SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus. Sharma K, et al. PLoS One, 2011. PMID 21637748, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
      Title: Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
    2. SARS-CoV ORF-9b manipulates host cell mitochondria and mitochondrial function to help evade host innate immunity.
      Title: SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome.
    3. Protein 6 immunoprecipitation from extracts of SARS-CoV infected cells and mass spectrometry analysis revealed an interaction of viral proteins 6 and 9b in biologically relevant conditions.
      Title: Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo.
    4. The structure of the Orf 9b protein consisted mostly of beta-sheet, and comprised only few alpha-helix.
      Title: [The cloning, expression and structural analysis of putative unknown protein Orf 9b in SARS-CoV].
    5. Putative virion assembly protein.
      Title: The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    ORF9b protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004718.3 Reference assembly

      Range
      28130..28426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009825062.1 ORF9b protein [SARS coronavirus Tor2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P59636, Q7T6R2
      UniProtKB/TrEMBL
      A0A3G5BJ10, B8Q8R1, B8Q8S3, B8Q8T4, B8Q8U5, B8Q8V6, B8Q8W7, C4P6R8, D2E1E3, D2E1F8, D2E231, D2E276, D3KDN5, Q19QV9, Q1T6W9, Q3S2B4, Q3ZTD0, Q4JDP4, Q692D6, Q6GYQ1, Q6R7X8, Q6RCV7, Q6RCW8, Q6RCX9, Q6RCZ0, Q6RD01, Q6RD12, Q6RD23, Q6RD34, Q6RD45, Q6RD56, Q6S8C6, Q6S8E0, Q6T1D1, Q6TPD9, Q6VA70, Q6VA81, Q6VA92, S5ZI77
      Conserved Domains (1) summary
      pfam09399
      Location:1 → 98
      SARS_lipid_bind; SARS lipid binding protein
    Nucleotide Protein
    Heading Accession and Version

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