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    RBMY1E RNA binding motif protein Y-linked family 1 member E [ Homo sapiens (human) ]

    Gene ID: 378950, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RBMY1Eprovided by HGNC
    Official Full Name
    RNA binding motif protein Y-linked family 1 member Eprovided by HGNC
    Primary source
    HGNC:HGNC:23916
    See related
    Ensembl:ENSG00000242389 AllianceGenome:HGNC:23916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 6.2) See more
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    Genomic context

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    See RBMY1E in Genome Data Viewer
    Location:
    Yq11.223
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (21902177..21918032, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (22737692..22753535, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24049769..24064179, complement)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377237 Neighboring gene RNA binding motif protein Y-linked family 1 member D Neighboring gene RNA binding motif protein Y-linked family 2 member A, pseudogene Neighboring gene OFD1 pseudogene 8 Y-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. Tsuei DJ, et al. Oncogene, 2004 Jul 29. PMID 15184870
    2. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. Prosser J, et al. Mamm Genome, 1996 Nov. PMID 8875892
    3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Ma K, et al. Cell, 1993 Dec 31. PMID 8269511
    4. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. Chai NN, et al. Genomics, 1998 Apr 15. PMID 9598316
    5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif protein, Y chromosome, family 1 member E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006118.3 → NP_001006118.2  RNA-binding motif protein, Y chromosome, family 1 member E

      See identical proteins and their annotated locations for NP_001006118.2

      Status: REVIEWED

      Source sequence(s)
      AC007322
      Consensus CDS
      CCDS35481.1
      UniProtKB/Swiss-Prot
      A6NCW6, A6NEG9, A6NEQ0, A6NKQ5, P0DJD4
      Related
      ENSP00000372105.2, ENST00000382659.7
      Conserved Domains (3) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      21902177..21918032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531494.4 → XP_011529796.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X2

      See identical proteins and their annotated locations for XP_011529796.1

      UniProtKB/Swiss-Prot
      P0DJD4
      Conserved Domains (3) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family

    2. XM_011531495.2 → XP_011529797.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X3

      UniProtKB/TrEMBL
      B7ZMC0
      Conserved Domains (3) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family

    3. XM_011531493.2 → XP_011529795.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X1

      UniProtKB/TrEMBL
      B7ZMC0, J3KPK3
      Related
      ENSP00000372104.4, ENST00000382658.5
      Conserved Domains (3) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family

    4. XM_047442738.1 → XP_047298694.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      22737692..22753535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328305.1 → XP_054184280.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X6

    2. XM_054328306.1 → XP_054184281.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X7

    3. XM_054328304.1 → XP_054184279.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X5

      UniProtKB/TrEMBL
      J3KPK3

    4. XM_054328307.1 → XP_054184282.1  RNA-binding motif protein, Y chromosome, family 1 member E isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NEQ0.1 GenPept UniProtKB/Swiss-Prot:A6NEQ0

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