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    igf1ra insulin-like growth factor 1a receptor [ Oryzias melastigma (Indian medaka) ]

    Gene ID: 112152311, updated on 10-Jul-2024

    Summary

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    Gene symbol
    igf1ra
    Gene description
    insulin-like growth factor 1a receptor
    See related
    EnsemblRapid:ENSOMEG00005015056
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryzias melastigma
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
    Orthologs
    human zebrafish all
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    Genomic context

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    See igf1ra in Genome Data Viewer
    Location:
    chromosome: LG6
    Exon count:
    20
    Annotation release Status Assembly LG Location
    101 current ASM292280v2 (GCF_002922805.2) LG6 NC_050517.1 (20523700..20605432, complement)
    100 previous assembly Om_v0.7.RACA (GCF_002922805.1) Unplaced Scaffold NW_020096088.1 (14550626..14632405)

    Linkage Group LG6 - NC_050517.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112152312 Neighboring gene synemin, intermediate filament protein Neighboring gene uncharacterized LOC118598865 Neighboring gene high-affinity choline transporter 1 Neighboring gene cilia and flagella associated protein 161

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-specific transcriptome assemblies of the marine medaka Oryzias melastigma and comparative analysis with the freshwater medaka Oryzias latipes. Lai KP, et al. BMC Genomics, 2015 Feb 27. PMID 25765076, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of insulin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor 1a receptor
    Names
    insulin-like growth factor 1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Oryzias melastigma Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM292280v2 Primary Assembly

    Genomic

    1. NC_050517.1 Reference ASM292280v2 Primary Assembly

      Range
      20523700..20605432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036212389.1 → XP_036068282.1  insulin-like growth factor 1a receptor isoform X1

      UniProtKB/TrEMBL
      A0A834FQJ9
      Conserved Domains (5) summary
      cd05032
      Location:1022 → 1296
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:496 → 604
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:610 → 649
      fn3; Fibronectin type III domain
      pfam00757
      Location:185 → 335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 467
      Recep_L_domain; Receptor L domain

    2. XM_024281804.2 → XP_024137572.1  insulin-like growth factor 1a receptor isoform X2

      UniProtKB/TrEMBL
      A0A3B3BIN0, A0A834FQJ9
      Related
      ENSOMEP00005034541.1, ENSOMET00005038237.1
      Conserved Domains (5) summary
      cd05032
      Location:995 → 1269
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:496 → 604
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:610 → 649
      fn3; Fibronectin type III domain
      pfam00757
      Location:185 → 335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 467
      Recep_L_domain; Receptor L domain
    Nucleotide Protein Strain
    Heading Accession and Version

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