CCL5 C-C motif chemokine ligand 5 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: CCL5
Gene description: C-C motif chemokine ligand 5
See related: Ensembl:ENSSSCG00000017705
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: SCYA5; RANTES; SIS-delta
Expression: Broad expression in spleen (RPKM 197.9), lung (RPKM 115.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	12	NC_010454.4 (39652731..39659121)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	12	NC_010454.3 (41218074..41228604)

Chromosome 12 - NC_010454.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Function of CCL5 in maternal-fetal interface of pig during early pregnancy.
Title: Function of CCL5 in maternal-fetal interface of pig during early pregnancy.
These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.
Title: Haemophilus parasuis infection activates chemokine RANTES in PK-15 cells.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.
Title: Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells.
we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription
Title: Molecular cloning of the porcine RANTES promoter: functional characterization of dsDNA/dsRNA response elements in PK-15 cells.
The Toll-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.
Title: Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells.
These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.
Title: Molecular characterization of miniature porcine RANTES and its chemotactic effect on human mononuclear cells.

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General gene information

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Markers

Rnu2 (e-PCR), detects polymorphism
- UniSTS:530590

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lymphocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-C motif chemokine 5

Names: Small-inducible cytokine A5; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.