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    ZBTB34 zinc finger and BTB domain containing 34 [ Homo sapiens (human) ]

    Gene ID: 403341, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZBTB34provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 34provided by HGNC
    Primary source
    HGNC:HGNC:31446
    See related
    Ensembl:ENSG00000177125 MIM:611692; AllianceGenome:HGNC:31446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF918
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.2), placenta (RPKM 3.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB34 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (126860639..126885878)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139066368..139092302)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129622918..129648157)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129482087-129482586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20291 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29019 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129567045-129567546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129594985-129595486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129595487-129595986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29023 Neighboring gene zinc finger and BTB domain containing 43 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129623061-129623858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129630751-129631332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:129645854-129646429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129648667-129649167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29025 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29031 Neighboring gene uncharacterized LOC105376279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129792702-129793202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129829482-129829982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129874135-129874746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129884227-129884860 Neighboring gene angiopoietin like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129884861-129885494

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. Qi J, et al. Mol Cell Biochem, 2006 Oct. PMID 16718364
    2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. Ohara O, et al. DNA Res, 2002 Apr 30. PMID 12056414
    3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li X, et al. Mol Syst Biol, 2015 Jan 21. PMID 25609649, Free PMC Article
    4. PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα. Ramberger E, et al. iScience, 2021 Jun 25. PMID 34189442, Free PMC Article
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22470, KIAA1993, MGC24652

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099270.4 → NP_001092740.2  zinc finger and BTB domain-containing protein 34 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL160169, AL354944
      Consensus CDS
      CCDS48023.2
      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A0C4DFQ2
      Related
      ENSP00000317534.4, ENST00000319119.5
      Conserved Domains (5) summary
      smart00355
      Location:376 → 398
      ZnF_C2H2; zinc finger
      sd00017
      Location:378 → 398
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:11 → 130
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:432 → 453
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:390 → 415
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001395198.1 → NP_001382127.1  zinc finger and BTB domain-containing protein 34 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL160169, AL354944
      Consensus CDS
      CCDS94483.1
      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A8Q3WKM1
      Related
      ENSP00000512077.1, ENST00000695642.1
      Conserved Domains (4) summary
      sd00017
      Location:388 → 408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:21 → 140
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:442 → 463
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:400 → 425
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      126860639..126885878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518699.4 → XP_011517001.1  zinc finger and BTB domain-containing protein 34 isoform X2

      See identical proteins and their annotated locations for XP_011517001.1

      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A0C4DFQ2
      Conserved Domains (5) summary
      smart00355
      Location:376 → 398
      ZnF_C2H2; zinc finger
      sd00017
      Location:378 → 398
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:11 → 130
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:432 → 453
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:390 → 415
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047423402.1 → XP_047279358.1  zinc finger and BTB domain-containing protein 34 isoform X1

      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A8Q3WKM1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      139066368..139092302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362986.1 → XP_054218961.1  zinc finger and BTB domain-containing protein 34 isoform X2

      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A0C4DFQ2

    2. XM_054362985.1 → XP_054218960.1  zinc finger and BTB domain-containing protein 34 isoform X1

      UniProtKB/Swiss-Prot
      Q38IA7, Q5VYE9, Q8NCN2
      UniProtKB/TrEMBL
      A0A8Q3WKM1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203482.1: Suppressed sequence

      Description
      NM_203482.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCN2.4 GenPept UniProtKB/Swiss-Prot:Q8NCN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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