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    cdc25c.L cell division cycle 25C L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398119, updated on 3-Jul-2024

    Summary

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    Official Symbol
    cdc25c.L
    Official Full Name
    cell division cycle 25C L homeolog
    Primary source
    Xenbase:XB-GENE-944825
    Locus tag
    XELAEV_18017344mg
    See related
    EnsemblRapid:ENSXLAG00005005607
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    cdc25; cdc25b; cdc25c; cdc25C2; xcdc25c; cdc25c-a; cdc25c-b; cdc25c.S; cdc25-1-b
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    Genomic context

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    See cdc25c.L in Genome Data Viewer
    Location:
    chromosome: 3L
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (55285439..55304281, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (40829222..40847954, complement)

    Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 23 L homeolog Neighboring gene GDNF family receptor alpha 3 L homeolog Neighboring gene oocyte-specific histone RNA stem-loop-binding protein 2-like Neighboring gene family with sequence similarity 53 member C L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Izumi T, et al. Mol Biol Cell, 1992 Aug. PMID 1392080, Free PMC Article
    2. Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. Wang R, et al. Proc Natl Acad Sci U S A, 2010 Nov 16. PMID 21041626, Free PMC Article
    3. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Kumagai A, et al. Cell, 1992 Jul 10. PMID 1623517
    4. Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends. McSherry TD, et al. Mol Cell Biol, 2004 Nov. PMID 15509799, Free PMC Article
    5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RSK2 phosphorylates three sites in Cdc25C and also partially activates Cdc25C.
      Title: Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    M-phase inducer phosphatase 1-B
    Names
    cell division cycle 25 homolog C
    cell division cycle 25C S homeolog
    tyrosine phosphatase
    NP_001081918.1
    XP_018106285.1
    XP_018106286.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088449.1 → NP_001081918.1  M-phase inducer phosphatase 1-B

      See identical proteins and their annotated locations for NP_001081918.1

      Status: PROVISIONAL

      Source sequence(s)
      M96858
      UniProtKB/Swiss-Prot
      P30308, P30309
      UniProtKB/TrEMBL
      A0A974HSI8, B7ZP67
      Related
      ENSXLAP00005016596.1, ENSXLAT00005016892.1
      Conserved Domains (2) summary
      cd01530
      Location:382 → 501
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:120 → 351
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      55285439..55304281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018250797.2 → XP_018106286.1  M-phase inducer phosphatase 1-B isoform X2

      UniProtKB/Swiss-Prot
      P30308
      UniProtKB/TrEMBL
      A0A8J0ULY0
      Related
      ENSXLAP00005016589.1, ENSXLAT00005016885.1

    2. XM_018250796.1 → XP_018106285.1  M-phase inducer phosphatase 1-B isoform X1

      UniProtKB/Swiss-Prot
      P30308, P30309
      UniProtKB/TrEMBL
      A0A974HSI8, B7ZP67
      Related
      ENSXLAP00005016563.1, ENSXLAT00005016859.1
      Conserved Domains (2) summary
      cd01530
      Location:382 → 501
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:120 → 351
      M-inducer_phosp; M-phase inducer phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30309.1 GenPept UniProtKB/Swiss-Prot:P30309

    Gene LinkOut

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