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    Tmem14a transmembrane protein 14A [ Mus musculus (house mouse) ]

    Gene ID: 75712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem14aprovided by MGI
    Official Full Name
    transmembrane protein 14Aprovided by MGI
    Primary source
    MGI:MGI:1922962
    See related
    Ensembl:ENSMUSG00000025933 AllianceGenome:MGI:1922962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTD011; 5730496E24Rik
    Summary
    Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and regulation of heme biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TMEM14A (transmembrane protein 14A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 12.5), frontal lobe adult (RPKM 9.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem14a in Genome Data Viewer
    Location:
    1 A4; 1 6.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21236609..21300391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21166436..21230167)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51618 Neighboring gene STARR-seq mESC enhancer starr_00396 Neighboring gene STARR-seq mESC enhancer starr_00397 Neighboring gene EF-hand domain (C-terminal) containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:20985434-20985617 Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560 Neighboring gene STARR-seq mESC enhancer starr_00399 Neighboring gene STARR-seq mESC enhancer starr_00401 Neighboring gene STARR-seq mESC enhancer starr_00402 Neighboring gene predicted gene, 32947 Neighboring gene predicted gene 28836 Neighboring gene STARR-seq mESC enhancer starr_00405 Neighboring gene STARR-seq mESC enhancer starr_00406 Neighboring gene glutathione S-transferase, alpha 3 Neighboring gene predicted pseudogene 7094

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 14A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290679.1 → NP_001277608.1  transmembrane protein 14A isoform 1

      See identical proteins and their annotated locations for NP_001277608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163025, AK017734, BC060034
      Consensus CDS
      CCDS69867.1
      UniProtKB/TrEMBL
      D3YV08
      Related
      ENSMUSP00000027064.8, ENSMUST00000027064.8
      Conserved Domains (1) summary
      pfam03647
      Location:4 → 86
      Tmemb_14; Transmembrane proteins 14C

    2. NM_029398.3 → NP_083674.2  transmembrane protein 14A isoform 2

      See identical proteins and their annotated locations for NP_083674.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-teriminus, compared to isoform 1.
      Source sequence(s)
      AC163025, BC060034
      Consensus CDS
      CCDS35523.1
      UniProtKB/Swiss-Prot
      P56983, Q8JZZ3
      Related
      ENSMUSP00000027065.6, ENSMUST00000027065.12
      Conserved Domains (1) summary
      pfam03647
      Location:4 → 87
      Tmemb_14; Transmembrane proteins 14C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      21236609..21300391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495579.3 → XP_006495642.1  transmembrane protein 14A isoform X1

      Conserved Domains (1) summary
      pfam03647
      Location:11 → 93
      Tmemb_14; Transmembrane proteins 14C

    2. XM_006495581.3 → XP_006495644.1  transmembrane protein 14A isoform X2

      Conserved Domains (1) summary
      pfam03647
      Location:11 → 94
      Tmemb_14; Transmembrane proteins 14C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56983.2 GenPept UniProtKB/Swiss-Prot:P56983

    Gene LinkOut

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