U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    TMEM232 transmembrane protein 232 [ Homo sapiens (human) ]

    Gene ID: 642987, updated on 27-Nov-2024

    Summary

    Official Symbol
    TMEM232provided by HGNC
    Official Full Name
    transmembrane protein 232provided by HGNC
    Primary source
    HGNC:HGNC:37270
    See related
    Ensembl:ENSG00000186952 MIM:620143; AllianceGenome:HGNC:37270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in flagellated sperm motility and spermatogenesis. Predicted to act upstream of or within maintenance of protein complex location and spermatid cytoplasm removal during spermiation of flagellated sperm. Predicted to be located in membrane. Predicted to be active in outer dense fiber. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.4) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM232 in Genome Data Viewer
    Location:
    5q22.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (110387431..110738954, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (110898553..111249587, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (109755197..110062372, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379119 Neighboring gene long intergenic non-protein coding RNA 1848 Neighboring gene PGAM family member 5, mitochondrial serine/threonine protein phosphatase pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 2532 Neighboring gene NANOG hESC enhancer GRCh37_chr5:109328178-109328712 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:109872134-109872982 Neighboring gene microRNA 548f-3 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:110027790-110028290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:110076045-110076546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:110076547-110077046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22887 Neighboring gene solute carrier family 25 member 46 Neighboring gene NANOG hESC enhancer GRCh37_chr5:110167579-110168112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:110229347-110229848 Neighboring gene integrin alpha FG-GAP repeat containing 2 pseudogene Neighboring gene BCL2 associated transcription factor 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog
    Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35903, FLJ43080, DKFZp686G0585

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of protein complex location IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatid cytoplasm removal during spermiation of flagellated sperm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in outer dense fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039763.4NP_001034852.3  transmembrane protein 232

      See identical proteins and their annotated locations for NP_001034852.3

      Status: VALIDATED

      Source sequence(s)
      AC010349, AK296542, BM465182
      Consensus CDS
      CCDS47253.2
      UniProtKB/Swiss-Prot
      B4DKF4, C9JQI7
      Related
      ENSP00000401477.2, ENST00000455884.7
      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      110387431..110738954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543565.4XP_011541867.1  transmembrane protein 232 isoform X11

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    2. XM_047417493.1XP_047273449.1  transmembrane protein 232 isoform X7

    3. XM_006714670.4XP_006714733.1  transmembrane protein 232 isoform X1

      See identical proteins and their annotated locations for XP_006714733.1

      UniProtKB/Swiss-Prot
      B4DKF4, C9JQI7
      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    4. XM_011543555.3XP_011541857.1  transmembrane protein 232 isoform X2

      See identical proteins and their annotated locations for XP_011541857.1

      Conserved Domains (1) summary
      pfam15877
      Location:23466
      TMEM232; Transmembrane protein family 232
    5. XM_011543552.3XP_011541854.1  transmembrane protein 232 isoform X1

      See identical proteins and their annotated locations for XP_011541854.1

      UniProtKB/Swiss-Prot
      B4DKF4, C9JQI7
      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    6. XM_011543556.3XP_011541858.1  transmembrane protein 232 isoform X2

      See identical proteins and their annotated locations for XP_011541858.1

      Conserved Domains (1) summary
      pfam15877
      Location:23466
      TMEM232; Transmembrane protein family 232
    7. XM_011543553.3XP_011541855.1  transmembrane protein 232 isoform X1

      See identical proteins and their annotated locations for XP_011541855.1

      UniProtKB/Swiss-Prot
      B4DKF4, C9JQI7
      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    8. XM_047417495.1XP_047273451.1  transmembrane protein 232 isoform X12

    9. XM_011543560.3XP_011541862.1  transmembrane protein 232 isoform X7

      Conserved Domains (1) summary
      pfam15877
      Location:1367
      TMEM232; Transmembrane protein family 232
    10. XM_047417492.1XP_047273448.1  transmembrane protein 232 isoform X6

    11. XM_047417491.1XP_047273447.1  transmembrane protein 232 isoform X4

    12. XM_011543559.3XP_011541861.1  transmembrane protein 232 isoform X5

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    13. XM_047417494.1XP_047273450.1  transmembrane protein 232 isoform X8

    14. XM_011543561.3XP_011541863.1  transmembrane protein 232 isoform X8

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    15. XM_011543563.3XP_011541865.1  transmembrane protein 232 isoform X10

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    16. XM_011543557.3XP_011541859.1  transmembrane protein 232 isoform X3

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    17. XM_017009706.3XP_016865195.1  transmembrane protein 232 isoform X9

    18. XM_017009705.3XP_016865194.1  transmembrane protein 232 isoform X3

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232
    19. XM_011543567.4XP_011541869.1  transmembrane protein 232 isoform X13

      Conserved Domains (1) summary
      pfam15877
      Location:42485
      TMEM232; Transmembrane protein family 232

    RNA

    1. XR_001742182.2 RNA Sequence

    2. XR_001742181.2 RNA Sequence

    3. XR_007058620.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      110898553..111249587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353093.1XP_054209068.1  transmembrane protein 232 isoform X11

    2. XM_054353088.1XP_054209063.1  transmembrane protein 232 isoform X7

    3. XM_054353079.1XP_054209054.1  transmembrane protein 232 isoform X1

    4. XM_054353082.1XP_054209057.1  transmembrane protein 232 isoform X2

    5. XM_054353081.1XP_054209056.1  transmembrane protein 232 isoform X1

    6. XM_054353083.1XP_054209058.1  transmembrane protein 232 isoform X2

    7. XM_054353080.1XP_054209055.1  transmembrane protein 232 isoform X1

    8. XM_054353094.1XP_054209069.1  transmembrane protein 232 isoform X12

    9. XM_054353089.1XP_054209064.1  transmembrane protein 232 isoform X7

    10. XM_054353087.1XP_054209062.1  transmembrane protein 232 isoform X6

    11. XM_054353085.1XP_054209060.1  transmembrane protein 232 isoform X4

    12. XM_054353086.1XP_054209061.1  transmembrane protein 232 isoform X5

    13. XM_054353090.1XP_054209065.1  transmembrane protein 232 isoform X8

    14. XM_054353092.1XP_054209067.1  transmembrane protein 232 isoform X10

    15. XM_054353084.1XP_054209059.1  transmembrane protein 232 isoform X3

    16. XM_054353091.1XP_054209066.1  transmembrane protein 232 isoform X9

    17. XM_054353095.1XP_054209070.1  transmembrane protein 232 isoform X13

    RNA

    1. XR_008487143.1 RNA Sequence

    2. XR_008487142.1 RNA Sequence