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    FRO8 ferric reduction oxidase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835081, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRO8
    Official Full Name
    ferric reduction oxidase 8
    Primary source
    TAIR:AT5G50160
    Locus tag
    AT5G50160
    See related
    Araport:AT5G50160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFRO8; ferric reduction oxidase 8; FERRIC REDUCTION OXIDASE 8; K6A12.2; K6A12_2
    Summary
    Encodes a ferric chelate reductase that is expressed in shoots and flowers.
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    Genomic context

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    See FRO8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (20415764..20418847)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NEP-interacting protein, putative (DUF239) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2 calcium/lipid-binding and GRAM domain containing protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana. Wu H, et al. Plant Cell Physiol, 2005 Sep. PMID 16006655
    2. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_124395.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ferric-chelate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric-chelate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ferric reduction oxidase 8
    NP_199827.2
    • ferric reduction oxidase 8 (FRO8); FUNCTIONS IN: oxidoreductase activity, ferric-chelate reductase activity; INVOLVED IN: oxidation reduction; LOCATED IN: mitochondrion, plasma membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Ferric reductase, NAD binding (InterPro:IPR013121), Cytochrome b245, heavy chain (InterPro:IPR000778), FAD-binding 8 (InterPro:IPR013112), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferric reductase-like transmembrane component, N-terminal (InterPro:IPR013130); BEST Arabidopsis thaliana protein match is: ferric reduction oxidase 1 (TAIR:AT1G01590.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20415764..20418847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344882.1 → NP_001331201.1  ferric reduction oxidase 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD89

    2. NM_124395.5 → NP_199827.2  ferric reduction oxidase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199827.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VY13, Q9FGS9
      UniProtKB/TrEMBL
      A0A654G9K9
      Conserved Domains (3) summary
      cd06186
      Location:321 → 495
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:1 → 728
      PLN02844; oxidoreductase/ferric-chelate reductase
      pfam01794
      Location:162 → 280
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VY13.1

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