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    sap130a Sin3A-associated protein a [ Danio rerio (zebrafish) ]

    Gene ID: 100073341, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sap130aprovided by ZNC
    Official Full Name
    Sin3A-associated protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070615-5
    See related
    Ensembl:ENSDARG00000056924 AllianceGenome:ZFIN:ZDB-GENE-070615-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162722
    Summary
    Predicted to enable glucan 1,4-alpha-glucosidase activity. Acts upstream of or within several processes, including floor plate formation; larval locomotory behavior; and thigmotaxis. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Used to study hypoplastic left heart syndrome. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See sap130a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (28018390..28049599)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (28027817..28059038)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene angiomotin like 2a Neighboring gene unconventional myosin-VIIa Neighboring gene si:ch73-194h10.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The complex genetics of hypoplastic left heart syndrome. Liu X, et al. Nat Genet, 2017 Jul. PMID 28530678, Free PMC Article
    2. Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. DeMoya RA, et al. Front Cell Dev Biol, 2023. PMID 37711853, Free PMC Article
    3. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glucan 1,4-alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floor plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within larval locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thigmotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase complex subunit SAP130a
    NP_001092247.2
    XP_005165953.1
    XP_009300663.1
    XP_017211908.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098777.2 → NP_001092247.2  histone deacetylase complex subunit SAP130a

      Status: VALIDATED

      Source sequence(s)
      CR626936, CR626940
      UniProtKB/TrEMBL
      A0A8M1NEX8, F1REK0
      Related
      ENSDARP00000112480.2, ENSDART00000123324.4
      Conserved Domains (1) summary
      pfam16014
      Location:651 → 1055
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      28018390..28049599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302388.4 → XP_009300663.1  histone deacetylase complex subunit SAP130a isoform X2

      UniProtKB/TrEMBL
      A0A8M3ATE0
      Conserved Domains (1) summary
      pfam16014
      Location:634 → 1038
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    2. XM_017356419.2 → XP_017211908.1  histone deacetylase complex subunit SAP130a isoform X3

      UniProtKB/TrEMBL
      A0A8M6YZH6

    3. XM_005165896.2 → XP_005165953.1  histone deacetylase complex subunit SAP130a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BD75
      Conserved Domains (1) summary
      pfam16014
      Location:650 → 1054
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394645.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      633..13975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395255.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      633..12572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395378.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      633..13975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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