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    CG31121 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42975, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG31121provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051121
    Locus tag
    Dmel_CG31121
    See related
    AllianceGenome:FB:FBgn0051121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH19411; CG11764; CG18633; CG18655; DmCG31121; Dmel\CG31121
    Summary
    Predicted to enable ATP binding activity. Is expressed in several structures, including extended germ band embryo; foregut primordium; hindgut anlage; presumptive embryonic/larval system; and trunk ectoderm. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG31121 in Genome Data Viewer
    Location:
    96B2-96B4; 3-86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24881466..24894605, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20707188..20720327, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    2. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
    3. Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster. Denecke S, et al. Proc Biol Sci, 2022 May 25. PMID 35582794, Free PMC Article
    4. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Ren Q, et al. Nucleic Acids Res, 2007 Jan. PMID 17135193, Free PMC Article
    5. ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile. He Q, et al. Int J Mol Sci, 2019 Mar 20. PMID 30897799, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31121-PA
    CG31121-PB
    NP_733058.1
    NP_733059.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24881466..24894605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170179.2 → NP_733058.1  uncharacterized protein Dmel_CG31121, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI14, Q8SXK9
      Related
      FBpp0084098
      Conserved Domains (3) summary
      TIGR01166
      Location:319 → 491
      cbiO; cobalt transport protein ATP-binding subunit
      pfam01061
      Location:621 → 809
      ABC2_membrane; ABC-2 type transporter
      cl21455
      Location:319 → 518
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_170180.2 → NP_733059.1  uncharacterized protein Dmel_CG31121, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI14, Q8SXK9
      Related
      FBpp0084099
      Conserved Domains (3) summary
      TIGR01166
      Location:319 → 491
      cbiO; cobalt transport protein ATP-binding subunit
      pfam01061
      Location:621 → 809
      ABC2_membrane; ABC-2 type transporter
      cl21455
      Location:319 → 518
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI14 Q0KI14
    Q8SXK9 Q8SXK9
    Q9VC17 Q9VC17

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