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    pcmt protein-L-isoaspartate (D-aspartate) O-methyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 30751, updated on 3-Dec-2024

    Summary

    Official Symbol
    pcmtprovided by ZNC
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-134
    See related
    Ensembl:ENSDARG00000015201 AllianceGenome:ZFIN:ZDB-GENE-990415-134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pimt; fj13d06; wu:fj13d06; etID309741.20
    Summary
    Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within regulation of calcium-mediated signaling. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm. Is expressed in brain; heart; liver; and pleuroperitoneal region. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See pcmt in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (1293985..1314427, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (1273159..1293747, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Neighboring gene low density lipoprotein receptor-related protein 11 Neighboring gene nucleoporin 43 Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein-L-isoaspartate(D-aspartate) O-methyltransferase
    Names
    l-isoaspartyl protein carboxyl methyltransferase
    protein L-isoaspartyl/D-aspartyl methyltransferase
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
    protein-beta-aspartate methyltransferase
    NP_571540.1
    XP_005160364.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131465.3NP_571540.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase

      See identical proteins and their annotated locations for NP_571540.1

      Status: VALIDATED

      Source sequence(s)
      BX248418, CR536610
      UniProtKB/Swiss-Prot
      Q92047
      UniProtKB/TrEMBL
      A0A8M2B749
      Related
      ENSDARP00000119861.1, ENSDART00000144288.3
      Conserved Domains (2) summary
      pfam01135
      Location:8216
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:11218
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      1293985..1314427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160307.5XP_005160364.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B749
      Related
      ENSDARP00000126988.1, ENSDART00000152436.2