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    BCL2L1 BCL2 like 1 [ Gallus gallus (chicken) ]

    Gene ID: 373954, updated on 8-Jun-2024

    Summary

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    Official Symbol
    BCL2L1provided by CGNC
    Official Full Name
    BCL2 like 1provided by CGNC
    Primary source
    CGNC:4663
    See related
    Ensembl:ENSGALG00010014066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    BCLX; BCL2L; bcl-x; Bcl-xl
    Orthologs
    human mouse all
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    Genomic context

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    See BCL2L1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (10357392..10375562, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (10139043..10157223, complement)

    Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene bactericidal permeability-increasing protein-like Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene TPX2, microtubule nucleation factor Neighboring gene myosin light chain kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of bcl-2 and bcl-x during chicken spermatogenesis. Vilagrasa X, et al. Mol Reprod Dev, 1997 May. PMID 9110311
    2. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Boise LH, et al. Cell, 1993 Aug 27. PMID 8358789
    3. The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers. Huang J, et al. Int J Environ Res Public Health, 2013 Dec 17. PMID 24351749, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups.
      Title: The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcl-2-like protein 1
    Names
    apoptosis regulator Bcl-X
    bcl2-L-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025304.1 → NP_001020475.1  bcl-2-like protein 1

      See identical proteins and their annotated locations for NP_001020475.1

      Status: PROVISIONAL

      Source sequence(s)
      U26645
      UniProtKB/Swiss-Prot
      Q07816, Q98908
      Conserved Domains (3) summary
      cd06845
      Location:80 → 190
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 217
      bcl-2; apoptosis regulator
      pfam02180
      Location:2 → 26
      BH4; Bcl-2 homology region 4

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10357392..10375562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015296319.4 → XP_015151805.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908
      Conserved Domains (3) summary
      cd06845
      Location:80 → 190
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 217
      bcl-2; apoptosis regulator
      pfam02180
      Location:2 → 26
      BH4; Bcl-2 homology region 4

    2. XM_015296317.4 → XP_015151803.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908
      Related
      ENSGALP00010019864.1, ENSGALT00010033754.1
      Conserved Domains (3) summary
      cd06845
      Location:80 → 190
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 217
      bcl-2; apoptosis regulator
      pfam02180
      Location:2 → 26
      BH4; Bcl-2 homology region 4

    3. XM_015296318.4 → XP_015151804.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908
      Conserved Domains (3) summary
      cd06845
      Location:80 → 190
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 217
      bcl-2; apoptosis regulator
      pfam02180
      Location:2 → 26
      BH4; Bcl-2 homology region 4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10139043..10157223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046930549.1 → XP_046786505.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908

    2. XM_046930548.1 → XP_046786504.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908

    3. XM_046930547.1 → XP_046786503.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07816, Q98908
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07816.2 GenPept UniProtKB/Swiss-Prot:Q07816

    Gene LinkOut

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