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    Ticam1 TIR domain containing adaptor molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363328, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ticam1provided by RGD
    Official Full Name
    TIR domain containing adaptor molecule 1provided by RGD
    Primary source
    RGD:1590868
    See related
    EnsemblRapid:ENSRNOG00000080915 AllianceGenome:RGD:1590868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; pattern recognition receptor signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of lymphocyte activation. Predicted to be located in cytosol and mitochondrion. Predicted to be part of ripoptosome. Predicted to be active in early endosome and endosome membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 24.7), Spleen (RPKM 23.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ticam1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1189717..1197730, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1102559..1111023, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10780185..10790280)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L35 like 3 Neighboring gene fem-1 homolog A Neighboring gene perilipin 3 Neighboring gene arrestin domain containing 5 Neighboring gene ubiquitin-like with PHD and ring finger domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Xu Y, et al. Immunity, 2007 Jul. PMID 17658277, Free PMC Article
    2. Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. Ebihara T, et al. J Exp Med, 2010 Nov 22. PMID 21059856, Free PMC Article
    3. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. Sato S, et al. J Immunol, 2003 Oct 15. PMID 14530355
    4. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Jiang Z, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14982987, Free PMC Article
    5. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Liu S, et al. Science, 2015 Mar 13. PMID 25636800

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within MyD88-independent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TRIF-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myeloid dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ripoptosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TIR domain containing adaptor molecule 1; TIR domain-containing adapter molecule 1
    Names
    toll-like receptor adaptor molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431327.1 → NP_001418256.1  TIR domain containing adaptor molecule 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5Y6Z3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1189717..1197730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596709.3 → XP_017452198.1  TIR domain-containing adapter molecule 1

      Related
      ENSRNOP00000076995.1, ENSRNOT00000072501.3
    Nucleotide Protein Strain
    Heading Accession and Version

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