U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    CDK20 cyclin dependent kinase 20 [ Homo sapiens (human) ]

    Gene ID: 23552, updated on 27-Nov-2024

    Summary

    Official Symbol
    CDK20provided by HGNC
    Official Full Name
    cyclin dependent kinase 20provided by HGNC
    Primary source
    HGNC:HGNC:21420
    See related
    Ensembl:ENSG00000156345 MIM:610076; AllianceGenome:HGNC:21420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P42; CCRK; CDCH; PNQALRE
    Summary
    The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
    Expression
    Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDK20 in Genome Data Viewer
    Location:
    9q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87966441..87974533, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (100120474..100128570, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90581356..90589448, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598, E3 ubiquitin ligase pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90566553-90567406 Neighboring gene uncharacterized LOC122394732 Neighboring gene uncharacterized LOC124902200 Neighboring gene uncharacterized LOC105376131 Neighboring gene RNA, U6 small nuclear 86, pseudogene Neighboring gene ribosomal protein S10 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in floor plate formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 20
    Names
    CAK-kinase p42
    CDK-activating kinase p42
    cell cycle-related kinase
    cell division protein kinase 20
    cyclin-dependent protein kinase H
    cyclin-kinase-activating kinase p42
    NP_001034892.1
    NP_001164110.1
    NP_001164111.1
    NP_036251.2
    NP_848519.1
    XP_016870050.1
    XP_016870051.1
    XP_016870052.1
    XP_016870053.1
    XP_047279074.1
    XP_047279075.1
    XP_047279076.1
    XP_047279077.1
    XP_047279078.1
    XP_047279080.1
    XP_047279081.1
    XP_054218535.1
    XP_054218536.1
    XP_054218537.1
    XP_054218538.1
    XP_054218539.1
    XP_054218540.1
    XP_054218541.1
    XP_054218542.1
    XP_054218543.1
    XP_054218544.1
    XP_054218545.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039803.3NP_001034892.1  cyclin-dependent kinase 20 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate, in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI479563, AL353572, BM982394
      Consensus CDS
      CCDS35060.1
      UniProtKB/Swiss-Prot
      A2A389, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q8IZL9, Q9BUF4
      UniProtKB/TrEMBL
      A0A0S2Z557
      Related
      ENSP00000322343.8, ENST00000325303.9
      Conserved Domains (2) summary
      PLN00009
      Location:1288
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3289
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
    2. NM_001170639.2NP_001164110.1  cyclin-dependent kinase 20 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BC002655, BM982394, CB992644
      Consensus CDS
      CCDS65075.1
      UniProtKB/TrEMBL
      A0A0S2Z566, A0A0S2Z5B6
      Related
      ENSP00000474485.1, ENST00000605159.5
      Conserved Domains (1) summary
      cd07832
      Location:3273
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
    3. NM_001170640.2NP_001164111.1  cyclin-dependent kinase 20 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 5, also known as cardiac CCRK), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS55324.1
      UniProtKB/TrEMBL
      A0A0S2Z535
      Related
      ENSP00000365031.3, ENST00000375871.8
      Conserved Domains (2) summary
      smart00220
      Location:4167
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3167
      PKc_like; Protein Kinases, catalytic domain
    4. NM_012119.5NP_036251.2  cyclin-dependent kinase 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS6677.1
      UniProtKB/TrEMBL
      A0A0S2Z566
      Related
      ENSP00000365043.3, ENST00000375883.7
      Conserved Domains (2) summary
      PLN00009
      Location:1267
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3268
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
    5. NM_178432.4NP_848519.1  cyclin-dependent kinase 20 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS6678.1
      UniProtKB/TrEMBL
      A0A0S2Z566
      Related
      ENSP00000338975.5, ENST00000336654.9
      Conserved Domains (2) summary
      PLN00009
      Location:1280
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3281
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      87966441..87974533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014563.3XP_016870052.1  cyclin-dependent kinase 20 isoform X8

    2. XM_017014564.3XP_016870053.1  cyclin-dependent kinase 20 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z562, A0A0S2Z566
      Conserved Domains (2) summary
      PLN00009
      Location:1259
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3260
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
    3. XM_047423121.1XP_047279077.1  cyclin-dependent kinase 20 isoform X6

    4. XM_017014561.3XP_016870050.1  cyclin-dependent kinase 20 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z557
    5. XM_017014562.3XP_016870051.1  cyclin-dependent kinase 20 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z557
    6. XM_047423124.1XP_047279080.1  cyclin-dependent kinase 20 isoform X10

    7. XM_047423122.1XP_047279078.1  cyclin-dependent kinase 20 isoform X7

    8. XM_047423119.1XP_047279075.1  cyclin-dependent kinase 20 isoform X2

    9. XM_047423118.1XP_047279074.1  cyclin-dependent kinase 20 isoform X1

    10. XM_047423120.1XP_047279076.1  cyclin-dependent kinase 20 isoform X4

    11. XM_047423125.1XP_047279081.1  cyclin-dependent kinase 20 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      100120474..100128570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362567.1XP_054218542.1  cyclin-dependent kinase 20 isoform X8

    2. XM_054362568.1XP_054218543.1  cyclin-dependent kinase 20 isoform X9

    3. XM_054362565.1XP_054218540.1  cyclin-dependent kinase 20 isoform X6

    4. XM_054362562.1XP_054218537.1  cyclin-dependent kinase 20 isoform X3

    5. XM_054362564.1XP_054218539.1  cyclin-dependent kinase 20 isoform X5

    6. XM_054362569.1XP_054218544.1  cyclin-dependent kinase 20 isoform X10

    7. XM_054362566.1XP_054218541.1  cyclin-dependent kinase 20 isoform X7

    8. XM_054362561.1XP_054218536.1  cyclin-dependent kinase 20 isoform X2

    9. XM_054362560.1XP_054218535.1  cyclin-dependent kinase 20 isoform X1

    10. XM_054362563.1XP_054218538.1  cyclin-dependent kinase 20 isoform X4

    11. XM_054362570.1XP_054218545.1  cyclin-dependent kinase 20 isoform X11