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    OCM oncomodulin [ Homo sapiens (human) ]

    Gene ID: 654231, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OCMprovided by HGNC
    Official Full Name
    oncomodulinprovided by HGNC
    Primary source
    HGNC:HGNC:8105
    See related
    Ensembl:ENSG00000122543 MIM:164795; AllianceGenome:HGNC:8105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OM; OCM1; ONCM
    Summary
    Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: There are two oncomodulin-like loci on chromosome 7 (GeneIDs 4951 and 654231). The nomenclature for the p and q arm locations was modified to agree with reports (including PMID: 1559707) that place the OCM gene on the p arm. [18 Jun 2007]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See OCM in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5859718..5886363)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5977469..6004117)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5899349..5925994)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ring finger protein 216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5775501-5776002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5776003-5776502 Neighboring gene microRNA 6874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5871051-5871551 Neighboring gene zinc finger protein 815, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1711 Neighboring gene RNA, 7SL, cytoplasmic 556, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25613 Neighboring gene nonconserved acetylation island sequence 61 enhancer Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene radial spoke head 10 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene PMS1 homolog 2, mismatch repair system component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. Kurimoto T, et al. J Neurosci, 2010 Nov 17. PMID 21084621, Free PMC Article
    2. The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. Pauls TL, et al. Biochim Biophys Acta, 1996 Apr 10. PMID 8611623
    3. Disulfide-linked dimer of oncomodulin: comparison to calmodulin. Mutus B, et al. Biochemistry, 1988 Jul 26. PMID 3179268
    4. Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. Tong B, et al. J Neurosci, 2016 Feb 3. PMID 26843644, Free PMC Article
    5. Human alpha and beta parvalbumins. Structure and tissue-specific expression. Föhr UG, et al. Eur J Biochem, 1993 Aug 1. PMID 8354278

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of oncomodulin in outer hair cells, leads to a progressive hearing loss in transgenic mice.
      Title: Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.
    2. Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
      Title: Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
    3. Ocm plays a central role in inflammation-induced regeneration in the optic nerve.
      Title: Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC97453, MGC97465, MGC97477, MGC142264, MGC142266

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oncomodulin-1
    Names
    beta parvalbumin
    hCG18255
    parvalbumin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097622.2 → NP_001091091.1  oncomodulin-1 isoform a

      See identical proteins and their annotated locations for NP_001091091.1

      Status: VALIDATED

      Source sequence(s)
      BC113704, CB045979, DB339645
      Consensus CDS
      CCDS43548.1
      UniProtKB/Swiss-Prot
      B9EJH7, P0CE72
      Related
      ENSP00000242104.5, ENST00000242104.6
      Conserved Domains (1) summary
      cd16255
      Location:9 → 109
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    2. NM_001391990.1 → NP_001378919.1  oncomodulin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC004983
      Consensus CDS
      CCDS43548.1
      UniProtKB/Swiss-Prot
      B9EJH7, P0CE72
      Conserved Domains (1) summary
      cd16255
      Location:9 → 109
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    3. NM_001391991.1 → NP_001378920.1  oncomodulin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004983
      Conserved Domains (2) summary
      cd16251
      Location:5 → 34
      EFh_parvalbumin_like; EF-hand motif [structural motif]
      cl25356
      Location:1 → 71
      EFh_parvalbumin_like; EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      5859718..5886363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420752.1 → XP_047276708.1  oncomodulin-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      5977469..6004117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358849.1 → XP_054214824.1  oncomodulin-1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CE72.1 GenPept UniProtKB/Swiss-Prot:P0CE72

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