adrb1.L adrenoceptor beta 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: adrb1.L
Official Full Name: adrenoceptor beta 1 L homeolog
Primary source: Xenbase:XB-GENE-6254043
Locus tag: XELAEV_18036640mg
See related: AllianceGenome:Xenbase:XB-GENE-6254043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: adrb1; X-Beta1AR
Summary: Predicted to enable beta1-adrenergic receptor activity. Predicted to act upstream of or within adenylate cyclase-activating adrenergic receptor signaling pathway; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; and positive regulation of heart rate by epinephrine-norepinephrine. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7S

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7S	NC_054384.1 (1957487..1959944)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7S	NC_030737.1 (1989184..1991237)

Chromosome 7S - NC_054384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables beta1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1 adrenergic receptor; beta-1 adrenergic receptor-like

Names: Beta-1 adrenoceptor; Beta-1 adrenoreceptor; adrenergic, beta-1-, receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.