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    HIV2gp4 vpr protein [ Human immunodeficiency virus 2 ]

    Gene ID: 1724718, updated on 17-Jul-2021

    Summary

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    Gene symbol
    HIV2gp4
    Gene description
    vpr protein
    Locus tag
    HIV2gp4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human immunodeficiency virus 2 (isolate: BEN)
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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    Genomic context

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    Location:
    clone: MK[2,6].
    Sequence:
    NC_001722.1 (6239..6502)

    NC_001722.1Genomic Context describing neighboring genes Neighboring gene gag polyprotein;gag-pol fusion polyprotein Neighboring gene vif protein Neighboring gene vpx protein Neighboring gene tat protein Neighboring gene rev protein Neighboring gene env polyprotein Neighboring gene nef protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001722.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. Li D, et al. mBio, 2020 Aug 4. PMID 32753492, Free PMC Article
    2. The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles. Shimagaki K, et al. J Gen Virol, 2020 Sep. PMID 32553018
    3. Morphological study on biologically distinct vpx/vpr mutants of HIV-2. Piroozmand A, et al. J Med Invest, 2006 Aug. PMID 16953064
    4. Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. Fregoso OI, et al. mBio, 2016 Sep 13. PMID 27624129, Free PMC Article
    5. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. Fregoso OI, et al. PLoS Pathog, 2013. PMID 23874202, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair.
      Title: HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair.
    2. The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles.
      Title: The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles.
    3. These data also indicate that HIV-1 and HIV-2 Vpr activate the DNA damage response through an SLX4-independent mechanism that remains uncharacterized.
      Title: Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment.
    4. Data suggest that, in an evolutionary model of virus-host interactions, binding of Vpx/Vpr with SAMHD1 (and subsequent degradation of SAMHD1 [SAM domain/HD domain-containing protein 1]) exhibits dynamic requirements that have toggled back and forth.
      Title: Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.
    5. results indicated that Vpx and Vpr of HIV-2 may cooperatively contribute to virion infectivity without affecting virion morphogenesis
      Title: Morphological study on biologically distinct vpx/vpr mutants of HIV-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    vpr protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001722.1 Reference assembly

      Range
      6239..6502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_056841.1 vpr protein [Human immunodeficiency virus 2]

      See identical proteins and their annotated locations for NP_056841.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P18100
      Conserved Domains (1) summary
      pfam00522
      Location:6 → 87
      VPR; VPR/VPX protein
    Nucleotide Protein
    Heading Accession and Version

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