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    QDR3 Qdr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852331, updated on 2-Nov-2024

    Summary

    Official Symbol
    QDR3
    Official Full Name
    Qdr3p
    Primary source
    SGD:S000000247
    Locus tag
    YBR043C
    See related
    AllianceGenome:SGD:S000000247; FungiDB:YBR043C; VEuPathDB:YBR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AQR2
    Summary
    Enables polyamine transmembrane transporter activity and threonine efflux transmembrane transporter activity. Involved in amino acid export across plasma membrane; ascospore wall assembly; and intracellular polyamine homeostasis. Located in cell periphery. Is active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See QDR3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (321876..323945, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid transporter FAT1 Neighboring gene putative acyltransferase Neighboring gene Tcm62p Neighboring gene tRNA-Val

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in amino acid export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular polyamine homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular polyamine homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in threonine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Qdr3p
    NP_009599.2
    • Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      321876..323945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178391.2NP_009599.2  TPA: Qdr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009599.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ43, P38227
      UniProtKB/TrEMBL
      C7GXW9, D3UED8, N1P6G2
      Conserved Domains (1) summary
      cd17323
      Location:110676
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily