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    UL1 envelope glycoprotein L [ Suid alphaherpesvirus 1 ]

    Gene ID: 2952527, updated on 18-Aug-2023

    Summary

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    Gene symbol
    UL1
    Gene description
    envelope glycoprotein L
    Locus tag
    SuHV1_gp56
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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    Genomic context

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    Sequence:
    NC_006151.1 (92475..95360, complement)

    NC_006151.1Genomic Context describing neighboring genes Neighboring gene tegument protein UL7 Neighboring gene capsid portal protein Neighboring gene helicase-primase helicase subunit Neighboring gene nuclear protein UL4 Neighboring gene protein V57 Neighboring gene nuclear protein UL3 Neighboring gene uracil-DNA glycosylase Neighboring gene miscRNA Neighboring gene ubiquitin E3 ligase ICP0 Neighboring gene transcriptional regulator ICP4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006151.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A). Böhm SW, et al. J Gen Virol, 2015 Aug. PMID 25908778
    2. Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H. Böhm SW, et al. J Virol, 2015 Jan 15. PMID 25392216, Free PMC Article
    3. The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion. Schröter C, et al. J Virol, 2014 Nov. PMID 25187552, Free PMC Article
    4. Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs. Böhm SW, et al. J Virol, 2016 Jan 1. PMID 26491153, Free PMC Article
    5. Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. Backovic M, et al. Proc Natl Acad Sci U S A, 2010 Dec 28. PMID 21149698, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results confirm the specificity of domain I for gL binding, demonstrate functional conservation of domain IV in two alphaherpesviruses from different genera, and indicate species-specific interactions of this domain with gB.
      Title: Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.
    2. Minor amounts of mature gH in virions are sufficient for productive replication.
      Title: A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A).
    3. These results indicate that the structure and flexibility of the syntaxin-like bundle of three alpha-helices are relevant for the function of pseudorabies virus glycoprotein H in membrane fusion.
      Title: Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H.
    4. Mutants expressing gH with serine(438) showed reduced fusion activity in transient-fusion assays and during infection, with delayed penetration kinetics and a small-plaque phenotype which indicates that proline(438) is important for efficient fusion.
      Title: The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion.
    5. Data show that the 2.1-A resolution structure of the core fragment of gH present in this chimera, bound to the Fab fragment of a PrV gH-specific monoclonal antibody.
      Title: Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: c92480-92475 experiment = consistent with mRNA sizes and sense in strain In-Fh , inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
    • Loc: c93362-93356 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
    • Loc: c94078-94072 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
    • Loc: c94940-94934 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
    • Loc: c95360-95354 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box

    General protein information

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    Preferred Names
    envelope glycoprotein L

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006151.1 Reference assembly

      Range
      92475..95360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_068376.1 envelope glycoprotein L [Suid alphaherpesvirus 1]

      See identical proteins and their annotated locations for YP_068376.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P52512
      UniProtKB/TrEMBL
      A0A2C9C2T8, G3G916, Q5PPA3
      Conserved Domains (1) summary
      PHA03298
      Location:86 → 140
      PHA03298; envelope glycoprotein L; Provisional
    Nucleotide Protein
    Heading Accession and Version

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