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    CSE2 Cse2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855744, updated on 1-Aug-2024

    Summary

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    Gene symbol
    CSE2
    Gene description
    Cse2p
    Primary source
    FungiDB:YNR010W
    Locus tag
    YNR010W
    See related
    SGD:S000005293; AllianceGenome:SGD:S000005293; VEuPathDB:YNR010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED9
    Summary
    Enables structural molecule activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CSE2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (643744..644193)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Nrm1p Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene uridine kinase URK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. Xiao ZX, et al. J Mol Biol, 1995 Apr 28. PMID 7739039
    2. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Xiao Z, et al. Mol Cell Biol, 1993 Aug. PMID 8336709, Free PMC Article
    3. SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Chen XH, et al. Mol Gen Genet, 1994 Aug 2. PMID 8058037
    4. Twelve open reading frames revealed in the 23.6 kb segment flanking the centromere on the Saccharomyces cerevisiae chromosome XIV right arm. Verhasselt P, et al. Yeast, 1994 Oct. PMID 7900425
    5. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cse2p
    NP_014407.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      643744..644193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183187.3 → NP_014407.3  TPA: Cse2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014407.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1I5, P33308
      UniProtKB/TrEMBL
      A6ZS84, B5VR41, C7GLP5, C8ZFN7, G2WL67, N1NWS4
      Conserved Domains (1) summary
      pfam07544
      Location:64 → 143
      Med9; RNA polymerase II transcription mediator complex subunit 9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33308.1

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