SFRP2 secreted frizzled related protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SFRP2provided by HGNC
Official Full Name: secreted frizzled related protein 2provided by HGNC
Primary source: HGNC:HGNC:10777
See related: Ensembl:ENSG00000145423 MIM:604157; AllianceGenome:HGNC:10777
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FRP-2; SARP1; SDF-5
Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Expression: Biased expression in urinary bladder (RPKM 276.9), gall bladder (RPKM 211.4) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q31.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (153780591..153789083, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (157105099..157113596, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (154701743..154710235, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development.
Title: A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development.
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance.
Title: Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance.
Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells.
Title: Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells.
Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma.
Title: Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma.
The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/beta-catenin signaling pathway.
Title: The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway.
Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2.
Title: Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2.
SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells.
Title: SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells.
Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from ""first contact"" interactions in the tumor microenvironment.
Title: Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from "first contact" interactions in the tumor microenvironment.
Evaluation of combined detection of multigene mutation and SDC2/SFRP2 methylation in stool specimens for colorectal cancer early diagnosis.
Title: Evaluation of combined detection of multigene mutation and SDC2/SFRP2 methylation in stool specimens for colorectal cancer early diagnosis.
Downregulation of SFRP2 facilitates cancer stemness and radioresistance of glioma cells via activating Wnt/beta-catenin signaling.
Title: Downregulation of SFRP2 facilitates cancer stemness and radioresistance of glioma cells via activating Wnt/β-catenin signaling.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W72225 (e-PCR)
- UniSTS:27293

SFRP2_3264.2 (e-PCR)
- UniSTS:468127

SHGC-68208 (e-PCR)
- UniSTS:55250

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	NAS Non-traceable Author Statement more info	PubMed
enables endopeptidase activator activity	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway involved in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac left ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte development	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in convergent extension involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dermatome development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesodermal cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in regulation of midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in sclerotome development	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell fate specification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: secreted frizzled-related protein 2

Names: SARP-1; sFRP-2; secreted apoptosis related protein 1; testicular tissue protein Li 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046941.1 RefSeqGene

Range

4994..13486

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003013.3 → NP_003004.1 secreted frizzled-related protein 2 precursor

See identical proteins and their annotated locations for NP_003004.1

Status: REVIEWED

Source sequence(s)

AA449032, AC020703, AF311912, AK075372, AK093922, BC008666, BM906663, BM924815, CN431016

Consensus CDS

CCDS34082.1

UniProtKB/Swiss-Prot

B3KQR2, O14778, Q96HF1, Q9HAP5

UniProtKB/TrEMBL

A0A140VJU3, B3KSM5

Related

ENSP00000274063.4, ENST00000274063.5

Conserved Domains (2) summary

cd07446
Location:36 → 163

CRD_SFRP2; Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity

cd03580
Location:169 → 295

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...