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    PVX_080100 multidrug resistance protein (mdr1) [ Plasmodium vivax (malaria parasite P. vivax) ]

    Gene ID: 5473000, updated on 17-May-2024

    Summary

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    Gene symbol
    PVX_080100
    Gene description
    multidrug resistance protein (mdr1)
    Primary source
    PlasmoDB:PVX_080100
    Locus tag
    PVX_080100
    See related
    VEuPathDB:PVX_080100
    Gene type
    protein coding
    RNA name
    multidrug resistance protein (mdr1)
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium vivax (strain: Salvador I)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Plasmodium)
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    Genomic context

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    See PVX_080100 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    1
    Sequence:
    Chromosome: 10; NC_009915.1 (361490..366095, complement)

    Chromosome 10 - NC_009915.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein, conserved Neighboring gene mitochondrial processing peptidase alpha subunit, putative Neighboring gene hypothetical protein, conserved Neighboring gene G10 protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009915.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination. Ngassa Mbenda HG, et al. Parasit Vectors, 2020 Feb 12. PMID 32051017, Free PMC Article
    2. Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region. Orjuela-Sánchez P, et al. Antimicrob Agents Chemother, 2009 Aug. PMID 19451296, Free PMC Article
    3. Drug resistance genes: pvcrt-o and pvmdr-1 polymorphism in patients from malaria endemic South Western Coastal Region of India. Joy S, et al. Malar J, 2018 Jan 19. PMID 29351800, Free PMC Article
    4. Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon. Melo GC, et al. PLoS One, 2014. PMID 25157811, Free PMC Article
    5. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Carlton JM, et al. Nature, 2008 Oct 9. PMID 18843361, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination.
      Title: Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination.
    2. The observed variations both in pvmdr-1 and pvcrt-o genes indicate a trend towards parasite acquiring CQ resistance in this endemic area.
      Title: Drug resistance genes: pvcrt-o and pvmdr-1 polymorphism in patients from malaria endemic South Western Coastal Region of India.
    3. chloroquine resistance and clinical severity in P. vivax infections are strongly associated with increased expression levels of the pvcrt-o and pvmdr-1 genes likely involved in chloroquine resistance. [pvcrt-o]
      Title: Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon.
    4. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of pvmdr1 genes revealed no associations with chloroquine resistance.
      Title: Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug resistance protein (mdr1)
    XP_001613728.1
    • encoded by transcript PVX_080100A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009915.1 Reference assembly

      Range
      361490..366095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001613678.1 → XP_001613728.1  multidrug resistance protein (mdr1) [Plasmodium vivax]

      See identical proteins and their annotated locations for XP_001613728.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A5K9C9, Q672L1, Q672L3, Q6IWB3
      Conserved Domains (3) summary
      PTZ00265
      Location:1 → 1464
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:66 → 309
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1164 → 1463
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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