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    IE180 transcriptional regulator ICP4 [ Suid alphaherpesvirus 1 ]

    Gene ID: 2952540, updated on 18-Aug-2023

    Summary

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    Gene symbol
    IE180
    Gene description
    transcriptional regulator ICP4
    Locus tag
    SuHV1_gp63
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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    Genomic context

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    Sequence:
    NC_006151.1 (102696..107804, complement)

    NC_006151.1Genomic Context describing neighboring genes Neighboring gene protein V57 Neighboring gene nuclear protein UL3 Neighboring gene uracil-DNA glycosylase Neighboring gene envelope glycoprotein L Neighboring gene miscRNA Neighboring gene ubiquitin E3 ligase ICP0 Neighboring gene regulatory protein ICP22 Neighboring gene serine/threonine protein kinase US3 Neighboring gene envelope glycoprotein G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006151.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a replication-incompetent pseudorabies virus mutant lacking the sole immediate early gene IE180. Wu BW, et al. mBio, 2014 Nov 11. PMID 25389174, Free PMC Article
    2. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus. Lerma L, et al. Virus Res, 2020 Apr 2. PMID 32045631
    3. The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α. Van Opdenbosch N, et al. J Virol, 2012 Jul. PMID 22532685, Free PMC Article
    4. Complete, annotated sequence of the pseudorabies virus genome. Klupp BG, et al. J Virol, 2004 Jan. PMID 14671123, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
      Title: Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
    2. IE180-null mutants failed to replicate new viral genomes, synthesize immediate early, early, or late viral proteins, and assemble infectious virions.
      Title: Characterization of a replication-incompetent pseudorabies virus mutant lacking the sole immediate early gene IE180.
    3. In conclusion, the immediate-early IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
      Title: The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: c102719-102714 experiment = consistent with mRNA size (sense unknown) in strain In-Fh , inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
    • Loc: c107804-107798 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box

    General protein information

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    Preferred Names
    transcriptional regulator ICP4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006151.1 Reference assembly

      Range
      102696..107804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_068382.1 transcriptional regulator ICP4 [Suid alphaherpesvirus 1]

      See identical proteins and their annotated locations for YP_068382.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P33479
      UniProtKB/TrEMBL
      A0A172XDM4, Q5PP75
      Conserved Domains (3) summary
      PHA03307
      Location:128 → 1351
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam03584
      Location:482 → 653
      Herpes_ICP4_N; Herpesvirus ICP4-like protein N-terminal region
      pfam03585
      Location:973 → 1350
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    Nucleotide Protein
    Heading Accession and Version

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