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    acp5a acid phosphatase 5a, tartrate resistant [ Danio rerio (zebrafish) ]

    Gene ID: 406801, updated on 4-Jan-2025

    Summary

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    Official Symbol
    acp5aprovided by ZNC
    Official Full Name
    acid phosphatase 5a, tartrate resistantprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2864
    See related
    Ensembl:ENSDARG00000019763 AllianceGenome:ZFIN:ZDB-GENE-040426-2864
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TRAP; acp5; sb:cb576; zgc:63825; wu:fb19f01; wu:fb30b03; wu:fi14e01; wu:fj66f03
    Summary
    Predicted to enable acid phosphatase activity; ferric iron binding activity; and ferrous iron binding activity. Predicted to be involved in bone resorption. Is expressed in several structures, including cranium; fin; hematopoietic system; scale; and yolk syncytial layer. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See acp5a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (8355229..8362506, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (8119690..8127061, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase a Neighboring gene uncharacterized LOC137490183 Neighboring gene interleukin enhancer binding factor 3a Neighboring gene prostaglandin E receptor 1a (subtype EP1) Neighboring gene uncharacterized LOC137495918

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An ancestral mycobacterial effector promotes dissemination of infection. Saelens JW, et al. Cell, 2022 Nov 23. PMID 36356582, Free PMC Article
    2. The zebrafish genome in context: ohnologs gone missing. Postlethwait JH. J Exp Zool B Mol Dev Evol, 2007 Sep 15. PMID 17068775
    3. Evaluation of Dexamethasone-Induced Osteoporosis In Vivo Using Zebrafish Scales. Chaichit S, et al. Pharmaceuticals (Basel), 2021 Jun 3. PMID 34205111, Free PMC Article
    4. Osteoclast-like Cells in Early Zebrafish Embryos. Sharif F, et al. Cell J, 2014 Summer. PMID 24567948, Free PMC Article
    5. Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Xu P, et al. J Ethnopharmacol, 2022 Jul 15. PMID 35398497

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tartrate-resistant acid phosphatase type 5a
    Names
    acid phosphatase 5, tartrate resistant
    tartrate-resistant acid phosphatase
    NP_999938.1
    XP_005165782.1
    XP_005165783.1
    XP_068077793.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214773.1 → NP_999938.1  tartrate-resistant acid phosphatase type 5a precursor

      See identical proteins and their annotated locations for NP_999938.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055256
      UniProtKB/TrEMBL
      A0A8M1PK00, Q7SXT1
      Related
      ENSDARP00000017532.8, ENSDART00000004716.10
      Conserved Domains (2) summary
      cd07378
      Location:36 → 319
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:36 → 251
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      8355229..8362506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221692.1 → XP_068077793.1  tartrate-resistant acid phosphatase type 5a isoform X2

    2. XM_005165726.5 → XP_005165783.1  tartrate-resistant acid phosphatase type 5a isoform X1

      See identical proteins and their annotated locations for XP_005165783.1

      UniProtKB/TrEMBL
      A0A8M1PK00, Q7SXT1
      Conserved Domains (2) summary
      cd07378
      Location:36 → 319
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:36 → 251
      Metallophos; Calcineurin-like phosphoesterase

    3. XM_005165725.5 → XP_005165782.1  tartrate-resistant acid phosphatase type 5a isoform X1

      See identical proteins and their annotated locations for XP_005165782.1

      UniProtKB/TrEMBL
      A0A8M1PK00, Q7SXT1
      Related
      ENSDART00000139161.3
      Conserved Domains (2) summary
      cd07378
      Location:36 → 319
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:36 → 251
      Metallophos; Calcineurin-like phosphoesterase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394626.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      208482..214159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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