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    AelPyV_gp4 large T antigen;small T antigen [ African elephant polyomavirus 1 ]

    Gene ID: 17099699, updated on 9-Sep-2020

    Summary

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    Gene symbol
    AelPyV_gp4
    Gene description
    large T antigen;small T antigen
    Locus tag
    AelPyV_gp4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    African elephant polyomavirus 1 (isolate: DK-1/2011, nat-host: Loxodonta africana)
    Lineage
    Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus
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    Genomic context

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    Sequence:
    NC_022519.1 (3458..5722, complement)

    NC_022519.1Genomic Context describing neighboring genes Neighboring gene minor capsid VP2 protein Neighboring gene minor capsid VP3 protein Neighboring gene major capsid protein VP1 Neighboring gene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_022519.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel polyomavirus isolated from a fibroma on the trunk of an African elephant (Loxodonta africana). Stevens H, et al. PLoS One, 2013. PMID 24205012, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    large T antigen;small T antigen
    YP_008603286.1
    • binds to the viral origin of replication; regulates the transcription of early region mRNA; helicase activity facilitates movement of the virion DNA replication fork; small T antigen shares a region in common with the large T antigen known as the J-domain; J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription
    YP_008603287.1
    • promotes the efficient replication of genomic DNA; binds to and negativley regulates the function of protein phosphotase (PP2A) thereby accelerating the progression to S-phase; shares a region in common with the large T-antigen known as the J-domain; J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_022519.1 Reference assembly

      Range
      3458..5722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_008603286.1 large T antigen [African elephant polyomavirus 1]

      See identical proteins and their annotated locations for YP_008603286.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      T2FG67
      Conserved Domains (3) summary
      PHA02624
      Location:1 → 637
      PHA02624; large T antigen; Provisional
      pfam02217
      Location:140 → 229
      T_Ag_DNA_bind; Origin of replication binding protein
      pfam06431
      Location:269 → 653
      Polyoma_lg_T_C; Polyomavirus large T antigen C-terminus

    2. YP_008603287.1 small T antigen [African elephant polyomavirus 1]

      See identical proteins and their annotated locations for YP_008603287.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      T2FF38
      Conserved Domains (3) summary
      pfam02380
      Location:98 → 171
      Papo_T_antigen; T-antigen specific domain
      PHA03102
      Location:7 → 150
      PHA03102; Small T antigen; Reviewed
      cl02542
      Location:33 → 59
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    Nucleotide Protein
    Heading Accession and Version

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