has2.S hyaluronan synthase 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: has2.S
Official Full Name: hyaluronan synthase 2 S homeolog
Primary source: Xenbase:XB-GENE-5775604
Locus tag: XELAEV_18033982mg
See related: EnsemblRapid:ENSXLAG00005022417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: has2; has2.L
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6S

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (125247551..125263279)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (116626511..116635108)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that hyaluronan newly synthesized by HAS2 and/or HAS3 is required for intestinal stem cell development through a positive feedback loop and is involved in the formation of the stem cell niche during metamorphosis.
Title: Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis.
In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC).
Title: XHas2 activity is required during somitogenesis and precursor cell migration in Xenopus development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endocardial cushion to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extracellular matrix assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extracellular polysaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hyaluronan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of urine volume	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within renal water absorption	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: hyaluronan synthase 2

Names: HA synthase 2; hyaluronan synthase 2 L homeolog; hyaluronate synthase 2; hyaluronic acid synthase 2; xHAS2

NP_001083837.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090368.1 → NP_001083837.1 hyaluronan synthase 2

See identical proteins and their annotated locations for NP_001083837.1

Status: PROVISIONAL

Source sequence(s)

AF168465

UniProtKB/Swiss-Prot

O57427

UniProtKB/TrEMBL

A0A974CKC0, V9TH72

Related

ENSXLAP00005065909.1, ENSXLAT00005067431.1

Conserved Domains (3) summary

cd06434
Location:84 → 361

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

TIGR04242
Location:48 → 463

nodulat_NodC; chitooligosaccharide synthase NodC

cl11394
Location:312 → 416

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold