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    T large T antigen;small T antigen [ Trichodysplasia spinulosa-associated polyomavirus ]

    Gene ID: 9486897, updated on 18-Aug-2023

    Summary

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    Gene symbol
    T
    Gene description
    large T antigen;small T antigen
    Locus tag
    TSaPV_gp4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Trichodysplasia spinulosa-associated polyomavirus (nat-host: Homo sapiens)
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Polyomaviridae
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    Genomic context

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    Sequence:
    NC_014361.1 (2528..5034, complement)

    NC_014361.1Genomic Context describing neighboring genes Neighboring gene structural protein VP2 Neighboring gene structural protein VP3 Neighboring gene structural protein VP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_014361.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa. van der Meijden E, et al. J Virol, 2015 Sep. PMID 26136575, Free PMC Article
    2. Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses. Wu JH, et al. J Clin Virol, 2016 Mar. PMID 26809132
    3. Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. van der Meijden E, et al. PLoS Pathog, 2010 Jul 29. PMID 20686659, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings support important role of trichodysplasia spinulosa-associated polyomavirus (TSPyV)-mediated pRb deactivation in development of trichodysplasia spinulosa (TS); observation that pRb tumor suppressor is inactivated by TSPyV sT but not Merkel cell polyomavirus sT provides further insights into the distinct pathobiological mechanisms of Merkel cell carcinoma and TS
      Title: Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses.
    2. this study provides valuable new insights into polyomavirus T gene use and expression.
      Title: Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    large T antigen;small T antigen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_014361.1 Reference assembly

      Range
      2528..5034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003800007.1 large T antigen [Trichodysplasia spinulosa-associated polyomavirus]

      See identical proteins and their annotated locations for YP_003800007.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3G1S4I4, E2ESL8
      Conserved Domains (1) summary
      PHA02624
      Location:1 → 672
      PHA02624; large T antigen; Provisional

    2. YP_003800008.1 small T antigen [Trichodysplasia spinulosa-associated polyomavirus]

      See identical proteins and their annotated locations for YP_003800008.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A068EUC0, E2ESL9, V5XW61
      Conserved Domains (3) summary
      pfam02380
      Location:92 → 186
      Papo_T_antigen; T-antigen specific domain
      smart00271
      Location:12 → 63
      DnaJ; DnaJ molecular chaperone homology domain
      PHA03102
      Location:7 → 163
      PHA03102; Small T antigen; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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