Nmdar1 NMDA receptor 1 [Apis mellifera (honey bee)] - Gene

Summary

Gene symbol: Nmdar1
Gene description: NMDA receptor 1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Apis mellifera
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
Also known as: NR1; GB19253; GB46886
Orthologs: fruit fly all
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Genomic context

Location:: chromosome: LG3

Exon count:: 19

Annotation release	Status	Assembly	LG	Location
104	current	Amel_HAv3.1 (GCF_003254395.2)	LG3	NC_037640.1 (4398525..4406208)
103	previous assembly	Amel_4.5 (GCF_000002195.4)	LG3	NC_007072.3 (2460629..2468312, complement)

Linkage Group LG3 - NC_037640.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distribution of the NR1 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR1 subunits were identified and compared.
Title: Comparative analysis of the locations of the NR1 and NR2 NMDA receptor subunits in honeybee (Apis mellifera) and fruit fly (Drosophila melanogaster, Canton-S wild-type) cerebral ganglia.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NMDA receptor 1

Names: NMDA-type glutamate receptor 1; NMDA-type glutamate receptor subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011573.1 → NP_001011573.1 NMDA receptor 1

See identical proteins and their annotated locations for NP_001011573.1

Status: PROVISIONAL

Source sequence(s)

AY331183

UniProtKB/TrEMBL

A0A7M6UUA5, A0A8B6WYW9, A0A8U0WQ63, Q4QYY7, Q7YXK7

Conserved Domains (6) summary

cd13719
Location:411 → 809

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:567 → 824

Lig_chan; Ligand-gated ion channel

pfam01094
Location:49 → 366

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:845 → 873

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:30 → 399

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:508 → 643

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Amel_HAv3.1 Primary Assembly

Genomic

NC_037640.1 Reference Amel_HAv3.1 Primary Assembly

Range

4398525..4406208

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006559677.3 → XP_006559740.1 NMDA receptor 1 isoform X1

UniProtKB/TrEMBL

A0A7M7GU82, A0A8B6YTM0

Conserved Domains (6) summary

cd13719
Location:411 → 808

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:566 → 823

Lig_chan; Ligand-gated ion channel

pfam01094
Location:49 → 366

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:844 → 872

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:30 → 399

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:507 → 642

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_026439306.1 → XP_026295091.1 NMDA receptor 1 isoform X2

UniProtKB/TrEMBL

A0A7M7L8C4, A0A8B8GTD1

Conserved Domains (3) summary

cd13719
Location:411 → 809

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:845 → 873

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:30 → 399

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
XM_026439307.1 → XP_026295092.1 NMDA receptor 1 isoform X3

UniProtKB/TrEMBL

A0A7M7MG21, A0A8B8GTU2

Conserved Domains (4) summary

cd13719
Location:107 → 505

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:304 → 359

Ion_trans_2; Ion channel

pfam10562
Location:541 → 569

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:4 → 95

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily