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    PSEN2 presenilin 2 [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105863820, updated on 13-Mar-2024

    Summary

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    Gene symbol
    PSEN2
    Gene description
    presenilin 2
    See related
    Ensembl:ENSMICG00000013427
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Also known as
    PS2; PS-2; PSNL2
    Orthologs
    human mouse all
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    Genomic context

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    See PSEN2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 17 NC_033676.1 (39467695..39493458)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012202130.1 (5094875..5120638, complement)

    Chromosome 17 - NC_033676.1Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene uncharacterized LOC105863821 Neighboring gene coenzyme Q8A Neighboring gene CDC42 binding protein kinase alpha Neighboring gene poly(ADP-ribose) glycohydrolase pseudogene Neighboring gene 60S ribosomal protein L6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the presenilin 2 cDNA and its distribution in brain of the primate, Microcebus murinus: coexpression with betaAPP and Tau proteins. Calenda A, et al. Neurobiol Dis, 1998 Nov. PMID 10069575

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    presenilin-2
    Names
    Presenilin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033676.1 Reference Mmur_3.0 Primary Assembly

      Range
      39467695..39493458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012751324.1 → XP_012606778.1  presenilin-2 isoform X1

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FEY9
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 500
      Presenilin; Presenilin

    2. XM_012751325.1 → XP_012606779.1  presenilin-2 isoform X2

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FES3
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 499
      Presenilin; Presenilin

    3. XM_012751326.1 → XP_012606780.1  presenilin-2 isoform X3

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FFR4
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 498
      Presenilin; Presenilin

    4. XM_020281452.1 → XP_020137041.1  presenilin-2 isoform X4

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8C5V4P5
      Related
      ENSMICP00000020216.2, ENSMICT00000038881.2
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 438
      Presenilin

    5. XM_012751327.1 → XP_012606781.1  presenilin-2 isoform X5

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FES0
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 437
      Presenilin; Presenilin

    6. XM_012751331.2 → XP_012606785.1  presenilin-2 isoform X8

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FFR9
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 400
      Presenilin; Presenilin

    7. XM_012751329.2 → XP_012606783.1  presenilin-2 isoform X6

      See identical proteins and their annotated locations for XP_012606783.1

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FEQ5
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 400
      Presenilin; Presenilin

    8. XM_012751330.2 → XP_012606784.1  presenilin-2 isoform X7

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FES9
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 400
      Presenilin; Presenilin

    9. XM_012751328.2 → XP_012606782.1  presenilin-2 isoform X6

      See identical proteins and their annotated locations for XP_012606782.1

      UniProtKB/Swiss-Prot
      P79801
      UniProtKB/TrEMBL
      A0A8B7FEQ5
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 400
      Presenilin; Presenilin

    10. XM_012751332.1 → XP_012606786.1  presenilin-2 isoform X9

      UniProtKB/TrEMBL
      A0A8B7FES5
      Conserved Domains (1) summary
      pfam01080
      Location:82 → 396
      Presenilin; Presenilin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79801.1 GenPept UniProtKB/Swiss-Prot:P79801

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