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    NOP15 rRNA-binding ribosome biosynthesis protein NOP15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855613, updated on 29-Jun-2024

    Summary

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    Gene symbol
    NOP15
    Gene description
    rRNA-binding ribosome biosynthesis protein NOP15
    Primary source
    FungiDB:YNL110C
    Locus tag
    YNL110C
    See related
    SGD:S000005054; AllianceGenome:SGD:S000005054; VEuPathDB:YNL110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human NIFK (nucleolar protein interacting with the FHA domain of MKI67). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOP15 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (417826..418488, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene Cyb5p Neighboring gene uncharacterized protein Neighboring gene YEATS domain-containing protein YAF9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Nop15p is an RNA-binding protein required for pre-rRNA processing and cytokinesis. Oeffinger M, et al. EMBO J, 2003 Dec 15. PMID 14657029, Free PMC Article
    2. Increased transcription of NOP15, involved in ribosome biogenesis in Saccharomyces cerevisiae, enhances the production yield of RNA as a source of nucleotide seasoning. Chuwattanakul V, et al. J Biosci Bioeng, 2012 Jul. PMID 22608550
    3. Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis. Paxman J, et al. Elife, 2022 Oct 4. PMID 36194205, Free PMC Article
    4. Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a pre-ribosomal RNA folding intermediate. Zhang J, et al. Nucleic Acids Res, 2017 Mar 17. PMID 27789691, Free PMC Article
    5. Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits. Dembowski JA, et al. Nucleic Acids Res, 2013 Sep. PMID 23788678, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the C-terminal residues of Nop15 are highly flexible, but essential for tight RNA binding
      Title: Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a pre-ribosomal RNA folding intermediate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rRNA-binding ribosome biosynthesis protein NOP15
    NP_014289.1
    • Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      417826..418488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182948.1 → NP_014289.1  TPA: rRNA-binding ribosome biosynthesis protein NOP15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014289.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W171, P53927
      UniProtKB/TrEMBL
      A0A8H4BWN9, A6ZRX2, B3LNW7, B5VQT4, C7GKD4, C8ZGC0, G2WLZ6, N1NZE0
      Conserved Domains (2) summary
      COG0724
      Location:4 → 203
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12552
      Location:92 → 168
      RRM_Nop15p; RNA recognition motif in yeast ribosome biogenesis protein 15 (Nop15p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53927.1

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