PZF1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PZF1
Primary source: FungiDB:YPR186C
Locus tag: YPR186C
See related: SGD:S000006390; AllianceGenome:SGD:S000006390; VEuPathDB:YPR186C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TFC2
Summary: Enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity and RNA polymerase III type 1 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Predicted to be active in nucleus. Orthologous to several human genes including ZFP14 (ZFP14 zinc finger protein); GTF3A (general transcription factor IIIA); and ZSCAN12 (zinc finger and SCAN domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in 5S class rRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015512.1

Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA

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The following sections contain reference sequences that belong to a specific genome build. Explain