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    JAK1 Janus kinase 1 [ Sus scrofa (pig) ]

    Gene ID: 397202, updated on 11-Apr-2024

    Summary

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    Official Symbol
    JAK1provided by VGNC
    Official Full Name
    Janus kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:89270
    See related
    Ensembl:ENSSSCG00000003809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in spleen (RPKM 63.8), lung (RPKM 63.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See JAK1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (147320288..147567188)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (135899431..135917892, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538066.1 (1..261, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538721.1 (1..365, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene adenylate kinase 4 Neighboring gene microRNA mir-101-2 Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene cache domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 U

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomic analysis reveals that transmissible gastroenteritis virus activates the JAK-STAT1 signaling pathway. An K, et al. J Proteome Res, 2014 Dec 5. PMID 25357264

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase JAK1
    NP_999279.1
    XP_020949185.1
    XP_020949186.1
    XP_020949187.1
    XP_020949189.1
    XP_020949190.1
    XP_020949191.1
    XP_020949192.1
    XP_020949193.1
    XP_020949194.1
    XP_020949195.1
    XP_020949196.1
    XP_020949197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214114.1 → NP_999279.1  tyrosine-protein kinase JAK1

      See identical proteins and their annotated locations for NP_999279.1

      Status: PROVISIONAL

      Source sequence(s)
      AB036335
      UniProtKB/TrEMBL
      A0A8D0IZ25, Q9TTJ1
      Conserved Domains (7) summary
      cd05079
      Location:857 → 1140
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00219
      Location:862 → 1136
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:25 → 274
      B41; Band 4.1 homologues
      cd05077
      Location:569 → 833
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:270 → 413
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam07714
      Location:569 → 832
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:413 → 513
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      147320288..147567188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021093532.1 → XP_020949191.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    2. XM_021093531.1 → XP_020949190.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    3. XM_021093538.1 → XP_020949197.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    4. XM_021093534.1 → XP_020949193.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    5. XM_021093526.1 → XP_020949185.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Related
      ENSSSCP00000075697.1, ENSSSCT00000096088.1
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    6. XM_021093527.1 → XP_020949186.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Related
      ENSSSCP00000032415.2, ENSSSCT00000045514.2
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    7. XM_021093528.1 → XP_020949187.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    8. XM_021093536.1 → XP_020949195.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    9. XM_021093537.1 → XP_020949196.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    10. XM_021093533.1 → XP_020949192.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    11. XM_021093535.1 → XP_020949194.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain

    12. XM_021093530.1 → XP_020949189.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      A0A286ZLI2, A0A8D1AD32, F1S818
      Related
      ENSSSCP00000079668.1, ENSSSCT00000092908.1
      Conserved Domains (5) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:37 → 286
      B41; Band 4.1 homologues
      cd05077
      Location:581 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 425
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:425 → 525
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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