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    Grap2 GRB2-related adaptor protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 17444, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Grap2provided by MGI
    Official Full Name
    GRB2-related adaptor protein 2provided by MGI
    Primary source
    MGI:MGI:1333842
    See related
    Ensembl:ENSMUSG00000042351 AllianceGenome:MGI:1333842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P38; GRID; Gads; GrbX; GrpL; Mona; GRB2L; GRBLG; Grf40; GRAP-2
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in cytosol; endosome; and nucleus. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in thymus adult (RPKM 26.9), spleen adult (RPKM 12.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grap2 in Genome Data Viewer
    Location:
    15 E1; 15 37.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80456798..80537055)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80572597..80652854)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23220 Neighboring gene ENTH domain containing 1 Neighboring gene predicted gene, 19141 Neighboring gene STARR-seq mESC enhancer starr_39234 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80402055-80402238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80402767-80403020 Neighboring gene STARR-seq mESC enhancer starr_39235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80460969-80461152 Neighboring gene STARR-positive B cell enhancer ABC_E942 Neighboring gene STARR-seq mESC enhancer starr_39236 Neighboring gene STARR-seq mESC enhancer starr_39237 Neighboring gene microRNA 6957 Neighboring gene RIKEN cDNA A430088P11 gene Neighboring gene STARR-positive B cell enhancer ABC_E608 Neighboring gene family with sequence similarity 83, member F Neighboring gene STARR-seq mESC enhancer starr_39239 Neighboring gene STARR-positive B cell enhancer ABC_E9421 Neighboring gene trinucleotide repeat containing 6b Neighboring gene STARR-seq mESC enhancer starr_39241 Neighboring gene STARR-positive B cell enhancer ABC_E7395 Neighboring gene STARR-seq mESC enhancer starr_39242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:80645405-80645514 Neighboring gene STARR-seq mESC enhancer starr_39245 Neighboring gene microRNA 5113

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of GADS enhances FLT3-induced mitogenic signaling. Chougule RA, et al. Oncotarget, 2016 Mar 22. PMID 26895103, Free PMC Article
    2. Gads-/- mice reveal functionally distinct subsets of TCRbeta+ CD4-CD8- double-negative thymocytes. Zeng L, et al. J Immunol, 2007 Jul 15. PMID 17617593
    3. Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage. Dalheimer SL, et al. Eur J Immunol, 2009 May. PMID 19337995, Free PMC Article
    4. Expression and function of the adaptor protein Gads in murine B cells. Yankee TM, et al. Eur J Immunol, 2005 Apr. PMID 15761845
    5. The Gads (GrpL) adaptor protein regulates T cell homeostasis. Yankee TM, et al. J Immunol, 2004 Aug 1. PMID 15265900

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High GADS expression is associated with neoplasms.
      Title: Expression of GADS enhances FLT3-induced mitogenic signaling.
    2. The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression
      Title: The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression.
    3. GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates.
      Title: Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.
    4. Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
      Title: Gads regulates the expansion phase of CD8+ T cell-mediated immunity.
    5. Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations.
      Title: Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
    6. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice
      Title: Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.
    7. Results reveal the basis for preferential recognition of specific LAT sites by Gads.
      Title: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
    8. Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
      Title: Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix.
    9. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. (Gab3 scaffolding protein)
      Title: Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.
    10. The Gads adaptor protein is critical for homeostasis of CD4(+) T cells.
      Title: The Gads (GrpL) adaptor protein regulates T cell homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-related adaptor protein 2
    Names
    GRB-2-like protein
    GRB-2-related monocytic adapter protein
    Grb2-related adaptor downstream of Sch
    adapter protein GRID
    growth factor receptor-binding protein
    hematopoietic cell-associated adaptor protein GrpL
    monocytic adapter
    monocytic adaptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289442.1 → NP_001276371.1  GRB2-related adaptor protein 2

      See identical proteins and their annotated locations for NP_001276371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC147041, BC052496
      Consensus CDS
      CCDS27663.1
      UniProtKB/Swiss-Prot
      O89100
      UniProtKB/TrEMBL
      Q3U0E8
      Related
      ENSMUSP00000155681.2, ENSMUST00000229980.2
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:267 → 319
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:2 → 53
      SH3; Src Homology 3 domain superfamily

    2. NM_010815.3 → NP_034945.1  GRB2-related adaptor protein 2

      See identical proteins and their annotated locations for NP_034945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC147041
      Consensus CDS
      CCDS27663.1
      UniProtKB/Swiss-Prot
      O89100
      UniProtKB/TrEMBL
      Q3U0E8
      Related
      ENSMUSP00000046532.8, ENSMUST00000043149.9
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:267 → 319
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:2 → 53
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      80456798..80537055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89100.1 GenPept UniProtKB/Swiss-Prot:O89100

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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