AZIN1 antizyme inhibitor 1 [Sorex araneus (European shrew)] - Gene

Summary

Gene symbol: AZIN1
Gene description: antizyme inhibitor 1
See related: EnsemblRapid:ENSSARG00000001295
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Sorex araneus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Soricinae; Sorex
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	mSorAra2.pri (GCF_027595985.1)	2	NC_073303.1 (123606289..123635993)
101	previous assembly	SorAra2.0 (GCF_000181275.1)	Unplaced Scaffold	NW_004545883.1 (21423914..21453390)

Chromosome 2 - NC_073303.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ornithine decarboxylase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ornithine decarboxylase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in putrescine biosynthetic process from ornithine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: antizyme inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291520.1 → NP_001278449.1 antizyme inhibitor 1

See identical proteins and their annotated locations for NP_001278449.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAQBIA010000019

Related

ENSSARP00000001180.2, ENSSART00000001290.2

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
NM_001301748.1 → NP_001288677.1 antizyme inhibitor 1

See identical proteins and their annotated locations for NP_001288677.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAQBIA010000019

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]