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    PLCB2 phospholipase C beta 2 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 453330, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLCB2provided by VGNC
    Official Full Name
    phospholipase C beta 2provided by VGNC
    Primary source
    VGNC:VGNC:3530
    Locus tag
    CK820_G0033474
    See related
    Ensembl:ENSPTRG00000006916
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See PLCB2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 16 NC_072414.2 (32245354..32269265, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 15 NC_072413.1 (32242046..32265700, complement)

    Chromosome 16 - NC_072414.2Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene PAK6 antisense RNA 1 Neighboring gene ankyrin repeat domain 63 Neighboring gene uncharacterized LOC129137204 Neighboring gene large ribosomal subunit protein uL10-like Neighboring gene uncharacterized LOC134808516

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    XP_009427073.1
    XP_009427074.1
    XP_009427075.1
    XP_009427079.1
    XP_009427080.1
    XP_009427081.1
    XP_009427082.1
    XP_009427084.1
    XP_054523341.1
    XP_054523342.1
    XP_054523344.1
    XP_063650802.1
    XP_063650803.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072414.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      32245354..32269265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054667367.2 → XP_054523342.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6

    2. XM_063794732.1 → XP_063650802.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10

      UniProtKB/TrEMBL
      A0A2I3TDM2

    3. XM_009428809.5 → XP_009427084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

      See identical proteins and their annotated locations for XP_009427084.1

      UniProtKB/TrEMBL
      A0A2I3TDM2, A0A2J8QDE3
      Conserved Domains (5) summary
      cd00275
      Location:677 → 798
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 645
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:974 → 1149
      PLC-beta_C; PLC-beta C terminal
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    4. XM_009428799.5 → XP_009427074.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

      Conserved Domains (8) summary
      cd00275
      Location:677 → 798
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 645
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02222
      Location:219 → 796
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:1065 → 1206
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1157 → 1167
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1054 → 1176
      GBP_C; Guanylate-binding protein, C-terminal domain

    5. XM_009428805.5 → XP_009427080.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9

      See identical proteins and their annotated locations for XP_009427080.1

      UniProtKB/TrEMBL
      A0A2I3TAY1, A0A2I3TDM2, A0A2J8QDE4, A0A6D2X5Y4
      Related
      ENSPTRP00000086369.1
      Conserved Domains (6) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:963 → 1138
      PLC-beta_C; PLC-beta C terminal
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
      cl25742
      Location:861 → 1058
      ERM; Ezrin/radixin/moesin family

    6. XM_054667366.2 → XP_054523341.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

      UniProtKB/TrEMBL
      A0A2I3TDM2

    7. XM_009428800.5 → XP_009427075.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

      See identical proteins and their annotated locations for XP_009427075.1

      UniProtKB/TrEMBL
      A0A2I3TDM2, A0A2J8QDF6, A0A6D2W3A1, H2Q961
      Related
      ENSPTRP00000011810.5
      Conserved Domains (5) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:978 → 1153
      PLC-beta_C; PLC-beta C terminal
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    8. XM_009428806.5 → XP_009427081.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11

      Conserved Domains (8) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02228
      Location:217 → 786
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:988 → 1129
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1080 → 1090
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:977 → 1099
      GBP_C; Guanylate-binding protein, C-terminal domain

    9. XM_054667369.2 → XP_054523344.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8

    10. XM_009428804.5 → XP_009427079.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7

      UniProtKB/TrEMBL
      A0A2I3TDM2
      Conserved Domains (8) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02228
      Location:217 → 786
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:1003 → 1144
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1095 → 1105
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:992 → 1114
      GBP_C; Guanylate-binding protein, C-terminal domain

    11. XM_009428798.5 → XP_009427073.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

      Conserved Domains (8) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02228
      Location:217 → 786
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:1069 → 1210
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1161 → 1171
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1058 → 1180
      GBP_C; Guanylate-binding protein, C-terminal domain

    12. XM_009428807.5 → XP_009427082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X12

      Conserved Domains (5) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02228
      Location:217 → 786
      PLN02228; Phosphoinositide phospholipase C
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    13. XM_063794733.1 → XP_063650803.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X13

      UniProtKB/TrEMBL
      A0A2I3SCP1, A0A2J8QDF0, A0A6D2X8V8

    RNA

    1. XR_010151599.1 RNA Sequence

    2. XR_010151600.1 RNA Sequence

    3. XR_010151598.1 RNA Sequence

    4. XR_010151597.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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