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    PF3D7_0300100 erythrocyte membrane protein 1, PfEMP1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 814321, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_0300100
    Gene description
    erythrocyte membrane protein 1, PfEMP1
    Primary source
    PlasmoDB:PF3D7_0300100
    Locus tag
    PF3D7_0300100
    See related
    VEuPathDB:PF3D7_0300100
    Gene type
    protein coding
    RNA name
    erythrocyte membrane protein 1, PfEMP1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0300100 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_000521.4 (36965..44482)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene rifin Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements. Muhle RA, et al. Int J Parasitol, 2009 Nov. PMID 19463825, Free PMC Article
    2. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855
    3. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556
    4. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings imply the existence of multiple levels of var gene regulation in addition to intrinsic promoter-dependent silencing.
      Title: A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    erythrocyte membrane protein 1, PfEMP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      36965..44482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351044.1 → XP_001351080.1  erythrocyte membrane protein 1, PfEMP1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351080.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0BTA0, O97324, W7K0N2
      Conserved Domains (5) summary
      PTZ00176
      Location:18 → 503
      PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
      pfam03011
      Location:586 → 729
      PFEMP; PFEMP DBL domain
      pfam15445
      Location:1755 → 2209
      ATS; acidic terminal segments, variant surface antigen of PfEMP1
      pfam05424
      Location:116 → 303
      Duffy_binding; Duffy binding domain
      pfam18562
      Location:1391 → 1443
      CIDR1_gamma; Cysteine-Rich Interdomain Region 1 gamma
    Nucleotide Protein
    Heading Accession and Version

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