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    cox8a cytochrome c oxidase subunit 8A [ Danio rerio (zebrafish) ]

    Gene ID: 557348, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cox8aprovided by ZNC
    Official Full Name
    cytochrome c oxidase subunit 8Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9136
    See related
    Ensembl:ENSDARG00000095273 AllianceGenome:ZFIN:ZDB-GENE-030131-9136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb01d11; coxXVIII; zehn2228; wu:fb01d11; hm:zehn2228
    Summary
    Predicted to act upstream of or within mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Is expressed in brain; gill; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 15. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cox8a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (28496193..28500703)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (28459498..28464008)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene phosphorylase, glycogen, muscle A Neighboring gene solute carrier family 22 member 6, like Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1a Neighboring gene ependymin-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP. Kim MJ, et al. Biotechniques, 2008 Sep. PMID 18778258
    2. A novel approach to study motor neurons from zebrafish embryos and larvae in culture. Sakowski SA, et al. J Neurosci Methods, 2012 Apr 15. PMID 22285259, Free PMC Article
    3. Enhanced antidiabetic efficacy and safety of compound K⁄β-cyclodextrin inclusion complex in zebrafish. Nam YH, et al. J Ginseng Res, 2017 Jan. PMID 28123328, Free PMC Article
    4. Nanoplastics Decrease the Toxicity of a Complex PAH Mixture but Impair Mitochondrial Energy Production in Developing Zebrafish. Trevisan R, et al. Environ Sci Technol, 2019 Jul 16. PMID 31259535, Free PMC Article
    5. Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish. Choi Y, et al. Anim Cells Syst (Seoul), 2021 Feb 11. PMID 33717419, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 8A, mitochondrial
    Names
    cytochrome c oxidase subunit VIIIA (ubiquitous)
    NP_001289982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303053.1 → NP_001289982.1  cytochrome c oxidase subunit 8A, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      CR749775, EH442681, EH443530
      UniProtKB/TrEMBL
      A0A8M1P768, E9QFA6
      Related
      ENSDARP00000119314.1, ENSDART00000138236.2
      Conserved Domains (1) summary
      pfam02285
      Location:29 → 69
      COX8; Cytochrome oxidase c subunit VIII

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      28496193..28500703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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