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    Ankle2 Ankle2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32732, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ankle2provided by FlyBase
    Official Full Name
    Ankle2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028343
    Locus tag
    Dmel_CG8465
    See related
    AllianceGenome:FB:FBgn0028343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ankle-2; anon-WO03040301.175; anon-WO03040301.177; anon-WO03040301.179; CG8465; dAnkle2; Dmel\CG8465; l(1)G0222; l(1)G0316
    Summary
    Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum and nuclear envelope. Is expressed in adult brain cell body rind; central brain primordium; embryonic brain; and organism. Used to study microcephaly and primary autosomal recessive microcephaly 16. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Ankle2 in Genome Data Viewer
    Location:
    16B5-16B6; 1-57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17571854..17579229, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17465887..17473262, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44692 Neighboring gene antisense RNA:CR44124 Neighboring gene pickpocket 23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene X11L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Shah PS, et al. Cell, 2018 Dec 13. PMID 30550790, Free PMC Article
    2. ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection. Thomas AX, et al. Ann Clin Transl Neurol, 2022 Aug. PMID 35871307, Free PMC Article
    3. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Yamamoto S, et al. Cell, 2014 Sep 25. PMID 25259927, Free PMC Article
    4. Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH). Naveed M, et al. Genet Res (Camb), 2018 Aug 8. PMID 30086807, Free PMC Article
    5. Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Link N, et al. Development, 2020 Sep 28. PMID 32988995, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ankle2
    Names
    ANKLE2 ortholog
    Ankle2-PD
    Ankle2-PE
    Ankle2-PF
    Ankle2-PG
    CG8465-PD
    CG8465-PE
    CG8465-PF
    CG8465-PG
    ankyrin repeat and LEM domain containing 2
    l(1)G0222
    lethal (1) G0222

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17571854..17579229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298446.1 → NP_001285375.1  Ankle2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCC5
      Conserved Domains (3) summary
      cd00204
      Location:243 → 375
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:282 → 361
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:280 → 335
      ANK; ANK repeat [structural motif]

    2. NM_132993.3 → NP_573221.2  Ankle2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573221.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHR1, Q8MQX9, Q9VX44, X2JCC5
      Conserved Domains (2) summary
      sd00045
      Location:280 → 335
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:281 → 361
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_167569.2 → NP_728082.2  Ankle2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728082.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHR1, Q8MQX9, Q9VX44, X2JCC5
      Conserved Domains (2) summary
      sd00045
      Location:280 → 335
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:281 → 361
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_167570.2 → NP_728083.2  Ankle2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728083.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX44
      Conserved Domains (3) summary
      cd00204
      Location:179 → 311
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:218 → 297
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:216 → 271
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQX9.1 Q8MQX9

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